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Objectives <p>Implementing a policy of genetic testing during a neurobehavioral psychiaty inpatient admission is an import part of clinical care delivery. We endeavor to understand behavioral outcomes after genetic testing is completed.</p> Methods <p>We completed a retrospective chart review on individuals receiving a clinical genetic evaluation for the indication of intellectual disability with autism and/or behavioral comorbidities during an inpatient admission to the pediatric neurobehavioral unit.</p> Results <p>In the cohort of 137 patients, 56 received a molecular diagnosis. On average, individuals in this diagnosed cohort had fewer inpatient hospital days after a molecular diagnosis was conferred compared to undiagnosed patients. These diagnosed patients had improvements in behavior measures, including lower scores on behavioral reactivity and self-injurious behavior severity. We present selected clinical vignettes illustrating examples of medical management changes implemented once a genetic diagnosis was delivered.</p> Conclusion <p>We posit that precision management of genetic syndromes may contribute to improved behavior symptoms and reduce the duration of inpatient stays for psychiatric behavioral management.</p>

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Conferring a Genetic Diagnosis for Children with Neurodevelopmental Disorders in the Inpatient Psychiatry Setting May Reduce Hospital Stays and Improve Behavior

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月24日

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  • Amelle Shillington,
  • Lori White,
  • Rachel Doberstein,
  • Robert J. Hopkin,
  • Katherine Zappia,
  • Katherine Harris,
  • Martine Lamy

摘要

Objectives

Implementing a policy of genetic testing during a neurobehavioral psychiaty inpatient admission is an import part of clinical care delivery. We endeavor to understand behavioral outcomes after genetic testing is completed.

Methods

We completed a retrospective chart review on individuals receiving a clinical genetic evaluation for the indication of intellectual disability with autism and/or behavioral comorbidities during an inpatient admission to the pediatric neurobehavioral unit.

Results

In the cohort of 137 patients, 56 received a molecular diagnosis. On average, individuals in this diagnosed cohort had fewer inpatient hospital days after a molecular diagnosis was conferred compared to undiagnosed patients. These diagnosed patients had improvements in behavior measures, including lower scores on behavioral reactivity and self-injurious behavior severity. We present selected clinical vignettes illustrating examples of medical management changes implemented once a genetic diagnosis was delivered.

Conclusion

We posit that precision management of genetic syndromes may contribute to improved behavior symptoms and reduce the duration of inpatient stays for psychiatric behavioral management.