Scholarlink

<p>Advances in nanotechnology contribute to the production of nanoparticles using environmentally friendly materials, with priority given to eliminating any production processes that produce toxic substances. use orange peels to synthesize zinc oxide nanoparticles by a sol-gel method, characterize them, and evaluate their effect on the MCF-7 cell line, as well as their haemolytic activity. Biosynthesis of zinc oxide nanoparticles (ZnO) using the sol-gel method was performed and characterized using UV-Vis, XRD, FESEM, FTIR, and GC-MS of orange peels, and evaluated on the MCF-7 cell line and haemolysis. The size ranged from 12 to 35&#xa0;nm, with the absorption peak reaching 333&#xa0;nm. Furthermore, the average size was 21&#xa0;nm. When chemical compounds of orange peel (sweet orange) were characterized, high concentrations of octanal, hexane, and limonene oxide were found, and the DPPH scavenging antioxidant capacity reached 75% at a concentration of 800&#xa0;mg/ml, respectively. Furthermore, the ROS and IC50 values ​​in live cells were 56.4% and59.51&#xa0;µg/ml respectively. The haemolysis rate remained relatively low at a concentration of 125&#xa0;mg/ml. However, a significant increase in cell deformation and haemolysis was observed with increasing concentration. Biosynthesis of zinc oxide/orange peel nanoparticles has shown promising potential in environmental and medical applications. The results indicate that these particles have promising biological effects, warranting further studies to evaluate their safety and efficacy in various medical applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Green synthesis of ZnO nanoparticles by orange peel: characterization, cytotoxicity, and hemolytic activity studies

  • 期刊论文

  • 发表日期：

    2026年1月9日

查看全文
  • Khalidah khalaf jabbar,
  • Salim Oudah Mezan,
  • Mohamed Bouaziz

摘要

Advances in nanotechnology contribute to the production of nanoparticles using environmentally friendly materials, with priority given to eliminating any production processes that produce toxic substances. use orange peels to synthesize zinc oxide nanoparticles by a sol-gel method, characterize them, and evaluate their effect on the MCF-7 cell line, as well as their haemolytic activity. Biosynthesis of zinc oxide nanoparticles (ZnO) using the sol-gel method was performed and characterized using UV-Vis, XRD, FESEM, FTIR, and GC-MS of orange peels, and evaluated on the MCF-7 cell line and haemolysis. The size ranged from 12 to 35 nm, with the absorption peak reaching 333 nm. Furthermore, the average size was 21 nm. When chemical compounds of orange peel (sweet orange) were characterized, high concentrations of octanal, hexane, and limonene oxide were found, and the DPPH scavenging antioxidant capacity reached 75% at a concentration of 800 mg/ml, respectively. Furthermore, the ROS and IC50 values ​​in live cells were 56.4% and59.51 µg/ml respectively. The haemolysis rate remained relatively low at a concentration of 125 mg/ml. However, a significant increase in cell deformation and haemolysis was observed with increasing concentration. Biosynthesis of zinc oxide/orange peel nanoparticles has shown promising potential in environmental and medical applications. The results indicate that these particles have promising biological effects, warranting further studies to evaluate their safety and efficacy in various medical applications.