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<p><i>Stephanotis floribunda</i> is a little-studied plant, and no research has been done on it in Tunisia until now. Phenolic compounds of different extracts from leaves and fruits were studied. This study adopted a new methodology, quick, easy, new, cheap, and reproducible assays (QUENCHER), in addition to the other extraction methods using solvents. Total phenolic compounds, antioxidant capacity in scavenging DPPH, and reducing power were determined. Gas chromatography (GC) analysis was used to determine the fatty acid content of <i>Stephanotis floribunda</i> oil. The most prevalent substances found in the phytochemical analysis, particularly linolenic acid, were examined in silico to forecast their biological function. Quencher extracts showed the highest content for all phenolic compounds for both studied organs. Acetone, water leaf extracts, and water fruit extracts exhibit the highest antioxidant activity against radical scavenging DPPH. Results showed that the amount of methanol leaf extract possesses the highest reducing power. For fruit extracts, the most significant reducing power was observed in the Quencher extract. Furthermore, linolenic acid, the most abundant compound found, has a strong affinity for heme oxygenase, indicating that it may have antioxidant properties through influencing this important enzyme in the synthesis of cytoprotective metabolites, according to in silico molecular modeling. This study will not only open up opportunities for developing therapeutic drugs targeting the heme oxygenase pathway for the treatment of oxidative stress-related diseases but also provide a molecular basis for explaining some of the medicinal properties traditionally attributed to<i> Stephanotis floribunda.</i></p>

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Evaluation in vitro and in silico antioxidant properties and characteristics of biomolecules in the ornamental plant Stephanotis floribunda: a conventional and quencher approach combined with plant oil analysis

  • 期刊论文

  • 发表日期：

    2025年9月9日

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  • Mouna Naouari,
  • Mohamed Mendili,
  • Mohamed Ali Smach,
  • Ayda Khadhri

摘要

Stephanotis floribunda is a little-studied plant, and no research has been done on it in Tunisia until now. Phenolic compounds of different extracts from leaves and fruits were studied. This study adopted a new methodology, quick, easy, new, cheap, and reproducible assays (QUENCHER), in addition to the other extraction methods using solvents. Total phenolic compounds, antioxidant capacity in scavenging DPPH, and reducing power were determined. Gas chromatography (GC) analysis was used to determine the fatty acid content of Stephanotis floribunda oil. The most prevalent substances found in the phytochemical analysis, particularly linolenic acid, were examined in silico to forecast their biological function. Quencher extracts showed the highest content for all phenolic compounds for both studied organs. Acetone, water leaf extracts, and water fruit extracts exhibit the highest antioxidant activity against radical scavenging DPPH. Results showed that the amount of methanol leaf extract possesses the highest reducing power. For fruit extracts, the most significant reducing power was observed in the Quencher extract. Furthermore, linolenic acid, the most abundant compound found, has a strong affinity for heme oxygenase, indicating that it may have antioxidant properties through influencing this important enzyme in the synthesis of cytoprotective metabolites, according to in silico molecular modeling. This study will not only open up opportunities for developing therapeutic drugs targeting the heme oxygenase pathway for the treatment of oxidative stress-related diseases but also provide a molecular basis for explaining some of the medicinal properties traditionally attributed to Stephanotis floribunda.