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<p>The goal of the agricultural chemicals manufacturing sector is to use the least quantity of pesticide necessary to achieve the best possible effects; the majority of chiral pesticides are synthesized and sold as racemates. In order to guarantee the proper active pesticide application rates, chiral separation is required for precise assessment of the stereoisomers in the designed product. In the present work, the chiral separation of six chiral synthetic pyrethroid insecticides (alpha-cypermethrin, lambda-cyhalothrin, fenvalerate, permethrin, tetramethrin, and cyfluthrin) was studied. The effect of the chiral stationary phase (CSP) (chiralcel OD-H, nucleocel alpha and nucleocel delta), the structure of analytes, the mobile phase proportion and the organic phase type under HPLC normal mode were estimated to assess the good resolution of its stereoisomers. The results indicated that when using the mobile phase of Heptane/2-propanol (98/2, v/v) with the Chiralcel OD-H column allowed the separation of six cyfluthrin stereoisomers, four α-Cypermethrin stereoisomers, four Fenvalerate stereoisomers, two tetramethrin stereoisomers, three permethrin stereoisomers and two λ-cyhalothrin stereoisomers. However, on Nucleocel alpha, λ-cyhalothrin stereoisomers in all the chromatographic conditions studied in the insecticides were not separated except for seven stereoisomers for cyfluthrin were separated and two stereoisomers for permethrin.</p> Graphical abstract <p></p>

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Effect of chemically bonded stationary phases, mobile phase composition and chemical structure analytes on six synthetic insecticides chiral resolution in high-performance liquid chromatography

  • 期刊论文

  • 发表日期：

    2025年5月7日

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  • Samira Ihadadene,
  • Dehbiya Gherdaoui,
  • Fairouz Tazerouti,
  • Lotfi Mouni,
  • Amine Aymen Assadi

摘要

The goal of the agricultural chemicals manufacturing sector is to use the least quantity of pesticide necessary to achieve the best possible effects; the majority of chiral pesticides are synthesized and sold as racemates. In order to guarantee the proper active pesticide application rates, chiral separation is required for precise assessment of the stereoisomers in the designed product. In the present work, the chiral separation of six chiral synthetic pyrethroid insecticides (alpha-cypermethrin, lambda-cyhalothrin, fenvalerate, permethrin, tetramethrin, and cyfluthrin) was studied. The effect of the chiral stationary phase (CSP) (chiralcel OD-H, nucleocel alpha and nucleocel delta), the structure of analytes, the mobile phase proportion and the organic phase type under HPLC normal mode were estimated to assess the good resolution of its stereoisomers. The results indicated that when using the mobile phase of Heptane/2-propanol (98/2, v/v) with the Chiralcel OD-H column allowed the separation of six cyfluthrin stereoisomers, four α-Cypermethrin stereoisomers, four Fenvalerate stereoisomers, two tetramethrin stereoisomers, three permethrin stereoisomers and two λ-cyhalothrin stereoisomers. However, on Nucleocel alpha, λ-cyhalothrin stereoisomers in all the chromatographic conditions studied in the insecticides were not separated except for seven stereoisomers for cyfluthrin were separated and two stereoisomers for permethrin.

Graphical abstract