<p>This review explores photocatalytic degradation as an innovative solution for antibiotic removal in wastewater, addressing limitations in traditional treatment plants that struggle with these contaminants. Persistent antibiotics in water ecosystems contribute to antimicrobial resistance, posing significant global health risks. Photocatalysis leverages light to activate catalysts that produce reactive oxygen species (ROS), which effectively degrade antibiotics like ciprofloxacin and tetracycline. The review analyses essential factors affecting this process, such as antibiotic concentration, catalyst type and quantity, light exposure duration, pH, oxidizing agents, and reaction kinetics. Examining recent studies highlights optimization strategies for photocatalysts to maximize degradation efficiency. This work underscores the potential of photocatalytic methods to improve wastewater treatment, offering a sustainable pathway to combat antibiotic pollution and its impact on ecosystems and public health.</p>