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<p>In the present study, an aqueous extract of the plant <i>Azadirachta indica</i> was used to synthesize zinc oxide nanoparticles (ZnONPs) and chitosan nanoparticles (CSNPs). Both nanoparticles were subjected to Fourier infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Scanning electron microscopy (SEM) with Energy-dispersive X-ray spectrometer (EDX), dynamic light scattering (DLS) and thermal gravimetric analysis (TGA) for characterization. FTIR analysis reveals distinct peaks corresponding to different functional groups in each material. The XRD spectra confirms the semi-crystalline structure of CSNPs and the amorphous character of ZnONPs, while SEM analysis shows rod shaped morphology for both nanoparticles. DLS analysis provides insights into the size distributions of synthesized ZnONPs and CSNPs. Evaluation of toxicity demonstrates concentration-dependent effects on zebrafish embryos, highlighting the importance of nanoparticle concentrations in biological applications. Antioxidant activity assays reveal potent scavenging properties of ZnONPs and CSNPs, with the scaffold showing slightly lower activity. Mechanical testing demonstrates the robustness of the Alginate-ZnONPs-CSNPs scaffold, and TGA analysis elucidates its thermal behavior. The prepared Scaffold should be studied in animal models in the near future for various biomedical applications.</p>

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Preparation of Zinc Oxide nanoparticle (ZnONPs)-Chitosan nanoparticle (CSNPs)-Alginate Scaffold for biological applications

  • 期刊论文

  • 发表日期：

    2025年2月5日

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  • Dhanasekar Nivetha,
  • Subburaman Chandramohan

摘要

In the present study, an aqueous extract of the plant Azadirachta indica was used to synthesize zinc oxide nanoparticles (ZnONPs) and chitosan nanoparticles (CSNPs). Both nanoparticles were subjected to Fourier infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Scanning electron microscopy (SEM) with Energy-dispersive X-ray spectrometer (EDX), dynamic light scattering (DLS) and thermal gravimetric analysis (TGA) for characterization. FTIR analysis reveals distinct peaks corresponding to different functional groups in each material. The XRD spectra confirms the semi-crystalline structure of CSNPs and the amorphous character of ZnONPs, while SEM analysis shows rod shaped morphology for both nanoparticles. DLS analysis provides insights into the size distributions of synthesized ZnONPs and CSNPs. Evaluation of toxicity demonstrates concentration-dependent effects on zebrafish embryos, highlighting the importance of nanoparticle concentrations in biological applications. Antioxidant activity assays reveal potent scavenging properties of ZnONPs and CSNPs, with the scaffold showing slightly lower activity. Mechanical testing demonstrates the robustness of the Alginate-ZnONPs-CSNPs scaffold, and TGA analysis elucidates its thermal behavior. The prepared Scaffold should be studied in animal models in the near future for various biomedical applications.