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Purpose <p>Investigate white matter alterations in chronic insomnia (CI) using Automated Fiber Quantification (AFQ).</p> Methods <p>Diffusion tensor imaging data from 49 CI patients and 27 healthy controls were profiled for fractional anisotropy (FA), axial/mean/radial diffusivity (AD/MD/RD) across 100 nodes of 18 tracts.</p> Results <p>CI showed increased AD in bilateral anterior thalamic radiations, right inferior longitudinal fasciculus, right arcuate fasciculus; increased MD in bilateral anterior thalamic radiations, right corticospinal tract, forceps minor of the corpus callosum, and right inferior longitudinal fasciculus. Changes in specific segments correlated significantly with clinical scores.</p> Conclusions <p>AFQ reveals fiber-specific abnormalities linked to clinical scores in CI.</p>

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White matter microstructural alterations in chronic insomnia: an automated fiber quantification study linking diffusion changes to symptom severity

  • 期刊论文

  • 发表日期：

    2026年3月30日

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  • Zhengwei Qu,
  • Wenzheng Zhang,
  • Maoyang Wang,
  • Wen Li,
  • Shengyan Miao,
  • Chenyu Wang,
  • Haizhu Xie,
  • Jun Li,
  • Xueyan Zhang

摘要

Purpose

Investigate white matter alterations in chronic insomnia (CI) using Automated Fiber Quantification (AFQ).

Methods

Diffusion tensor imaging data from 49 CI patients and 27 healthy controls were profiled for fractional anisotropy (FA), axial/mean/radial diffusivity (AD/MD/RD) across 100 nodes of 18 tracts.

Results

CI showed increased AD in bilateral anterior thalamic radiations, right inferior longitudinal fasciculus, right arcuate fasciculus; increased MD in bilateral anterior thalamic radiations, right corticospinal tract, forceps minor of the corpus callosum, and right inferior longitudinal fasciculus. Changes in specific segments correlated significantly with clinical scores.

Conclusions

AFQ reveals fiber-specific abnormalities linked to clinical scores in CI.