Scholarlink

<p>This pilot study investigated the impact of a 24-h sleep deprivation period on circulating biomarkers of creatine metabolism in 23 healthy adults (24.6 ± 4.3&#xa0;years; 7 females). Contrary to the hypothesis that sleep deprivation would reduce creatine levels, serum creatine significantly increased post-deprivation (95% CI −3.66 to 25.22&#xa0;μmol/L; <i>P</i> = 0.03), while guanidinoacetic acid and creatinine levels remained unchanged. Our findings suggest a complex relationship between sleep deprivation and creatine metabolism, emphasizing the need for further research using advanced biomarkers to elucidate these mechanisms and assess creatine’s potential protective role under stress conditions.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Sleep deprivation elevates circulating creatine levels in healthy adults: a pilot study

  • 期刊论文

  • 发表日期：

    2025年4月21日

查看全文
  • Nikola Todorovic,
  • David Nedeljkovic,
  • Jovana Panic,
  • Sergej M. Ostojic

摘要

This pilot study investigated the impact of a 24-h sleep deprivation period on circulating biomarkers of creatine metabolism in 23 healthy adults (24.6 ± 4.3 years; 7 females). Contrary to the hypothesis that sleep deprivation would reduce creatine levels, serum creatine significantly increased post-deprivation (95% CI −3.66 to 25.22 μmol/L; P = 0.03), while guanidinoacetic acid and creatinine levels remained unchanged. Our findings suggest a complex relationship between sleep deprivation and creatine metabolism, emphasizing the need for further research using advanced biomarkers to elucidate these mechanisms and assess creatine’s potential protective role under stress conditions.