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<p>Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive decline in cognitive function and emotional disturbances. The amygdala is an important connectivity structure in the brain and is responsible for emotional responses. 5-HT is involved in various neurodevelopmental processes in the brain. In this study, correlation study of 5-HT in brain with cognitive function and anxious-like behavior was investigated in APP/PS1 transgene mice. Multiple behavioral tests were performed to examine the cognitive function and anxiety behavior of AD mice. In vivo hippocampus long-term potentiation (LTP) was recorded to reflect synaptic plasticity. 5-HT levels in hippocampus and amygdala were determined. Further, we explored the correlation between 5-HT levels in hippocampus and amygdala and long-term cognitive behaviors and anxiety behaviors in the AD mice using linear regression analysis. Our results demonstrated that there was close linear correlation between 5-HT level in brain and spatial cognition and anxiety behavior of APP/PS1 transgene mice. 5-HT influences spatial learning and memory by regulating the synaptic plasticity in hippocampus of APP/PS1 transgenic mice. These results indicate that 5-HT might be potentially beneficial in the treatment of AD.</p>

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Correlation study of 5-HT in brain with cognitive function and anxious-like behavior in APP/PS1 transgene mice

  • 期刊论文

  • 发表日期：

    2025年3月20日

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  • Li Yuan,
  • Linshan An,
  • Rui Xie,
  • Jiahong Cai,
  • Dong Li,
  • Xiaorong Chen,
  • Wenjing Guo,
  • Yinran Lin,
  • Chunjing Zhu,
  • Yongli Chang,
  • Kunbo Wang,
  • Weina Han,
  • Lingna Han

摘要

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive decline in cognitive function and emotional disturbances. The amygdala is an important connectivity structure in the brain and is responsible for emotional responses. 5-HT is involved in various neurodevelopmental processes in the brain. In this study, correlation study of 5-HT in brain with cognitive function and anxious-like behavior was investigated in APP/PS1 transgene mice. Multiple behavioral tests were performed to examine the cognitive function and anxiety behavior of AD mice. In vivo hippocampus long-term potentiation (LTP) was recorded to reflect synaptic plasticity. 5-HT levels in hippocampus and amygdala were determined. Further, we explored the correlation between 5-HT levels in hippocampus and amygdala and long-term cognitive behaviors and anxiety behaviors in the AD mice using linear regression analysis. Our results demonstrated that there was close linear correlation between 5-HT level in brain and spatial cognition and anxiety behavior of APP/PS1 transgene mice. 5-HT influences spatial learning and memory by regulating the synaptic plasticity in hippocampus of APP/PS1 transgenic mice. These results indicate that 5-HT might be potentially beneficial in the treatment of AD.