<p>Pre-stressed concrete bridges have superior strength and load-bearing capability, making them more cost-effective and efficient than reinforced concrete bridges. PSC box-girder bridges integrate the advantages of prestressed concrete and the box-girder configuration, yielding improved torsional and flexural rigidity, significant shear strength, and efficient load distribution over the structure. These bridges are suitable for long spans, reduce deflection under load, enhance aesthetic and functional performance, demonstrate high durability, facilitate rapid construction, possess an excellent ratio of stiffness/mass, and lower self-weight criteria for contemporary infrastructure standards. Box girder bridges provide significant design challenges for engineers due to their complicated form, structural integrity, and higher difficulty across various loading situations. The comprehensive analysis of PSC box-girder bridges subjected to railway vehicle loads, wind forces, and seismic events is crucial for ensuring their safety and durability. The challenges in the dynamic study of this bridge involve accurate modelling of the complicated connection among the vehicle and the bridge, along with addressing uncertainties in material properties, geometric dimensions, and loading conditions. Prior studies have not employed efficient and rapid computational models of the bridge, train car, and track utilizing a non-closed form solution analysis (FEM). Nevertheless, it has not examined the impact of the prestressing force or the uncertainties associated with material attributes, geometries, and loads under appropriate boundary conditions. The main theme is to examine the response of the PSC box girder bridge to fast trains by investigating the dynamic effects of train speed, load case position, damping, pre-stressing force, positioning and the amount of pretensioning tendons, and the characteristics of the railway track on the 3D modelling of the PSC box girder bridge without a ballast railway trackframe work. The dynamic performance of the PSC box girder bridge was executed using the non-closed form FEM and ANSYS 2024 software. Confirmed the model’s dependability through mesh converge evaluation and contrasted it with findings from earlier research. An investigation was conducted on several factors that influence the dynamic characteristics of the PSC box girder bridge such as speed of train vehicle, location of load case, damping, pre-stressing force, location and no of pretensioning tendons, and railway track. The study of the PSC box girder bridge focused on identifying the most severe railway loading situations that could affect its dynamic behaviour. This investigation is confined to the dynamic analysis of the PSC box-girder bridge system. This article assesses numerous extensive studies on the variable attributes of a PSC box-girder bridge system under various loading conditions, load case combinations, and vehicle speeds. The outcomes of this work are essential for bridge technicians, providing significant information to enhance their understanding of the fluctuating characteristics of a PSC box-girder bridge. This information may aid bridge and rail engineers in assessing the life under fatigue prediction of PSC box-girder bridges subjected to automotive live loads and seismic challenges.</p>