<p>The seismic vulnerability of masonry infill walls within reinforced concrete (RC) frames poses significant challenges to structural integrity. This study investigates the performance of masonry infill walls using a detailed micro-modeling approach in Abaqus to enhance the understanding of their behavior under lateral cyclic loading. Unlike traditional macro-modeling techniques, the micro-modeling approach used in this research simulates individual masonry units and mortar joints, providing a more comprehensive representation of the infill wall’s response. Experimental data from literature was utilized to replicate the RC frame’s dimensions, material properties, and loading conditions. The study focuses on a single-bay RC frame with a masonry infill wall without openings, subjected to quasi-static cyclic lateral loads. Key findings reveal that the micro-modeling approach closely aligns with experimental load-deformation behavior, with the computational model estimating a maximum capacity of 26.42 tons, compared to the experimental result of 30.78 tons. This slight variation underscores the potential for further refinement in the computational model to improve accuracy. Overall, this research demonstrates the effectiveness of micro-modeling in capturing the complex interactions between the RC frame and masonry infill, offering valuable insights for the seismic design of infill walls.</p>