<p>Porphyry Polymetallic Deposits (PPDs) are generated in two different tectonic settings, oceanic subduction zones and continental zones including continental collision zones and intracontinental orogenic belts, which are referred to as oceanic and continental types in this article. Such deposits produced in different tectonic settings have similarities and their own unique geology, lithochemistry and geochemistry. Based on a review of the spatiotemporal distribution of oceanic and continental PPDs around the world, and a summary of their geology, lithochemistry, geochemistry, mineralization controls such as the degree of magma differentiation and oxidizability, the authors of this paper summarize the prospecting indicators and directions of such deposits from the perspective of the development of modern science and technology: unique topography and landforms, traditional geology, geophysics, remote sensing, lithochemistry, and geochemistry, characteristic minerals such as hornblende that indicate the degree of magma differentiation, and special lithochemical-geochemical eigenvalues including oxygen fugacity or magmatic oxidizability ΔFMQ, Zr/Hf, La/Ta, Y/Ho, La/Nb, K/Rb, LREE/HREE, Rb/Sr, Rb/Ba, A/CNK, Zr + Nb + Ce + Y, V/Sc, Zn/Fe, Fe³⁺/ΣFe, Eu/Eu*, decoupling of twin element pairs (mainly Nb–Ta and Zr-Hf), and tetrad effects of REEs, etc. The fact that large and super-large PPDs including Porphyry Copper Polymetallic Deposits (PCPDs) have been discovered around the world in the past decade shows that traditional geological techniques, including geochemical, geophysical explorations and remote sensing, are still indispensable means for the prospecting and exploration of such deposits. However, with the great progress of science and technology and the further improvement of the accuracy of test and analysis methods, technical means such as geophysical exploration and remote sensing have become more diverse, accurate and fast. There is no doubt that comprehensive analysis of the above-mentioned lithochemical-geochemical eigenvalues of porphyry is also one of the important means to evaluate whether a rock body contains minerals or what kind of metal minerals it contains. The organic combination of traditional geology, lithochemistry-geochemistry, geophysics, remote sensing and AI to evaluate, explore and develop minerals is both economical and fast, and is also an important direction at present and in the future.</p>