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<p>Chronic ethanol consumption poses significant threats to renal health, leading to oxidative stress and inflammation, which can exacerbate kidney dysfunction. The aim of this study was to investigate the protective effects of losartan, an angiotensin II receptor blocker, against ethanol-induced renal damage in male Wistar rats. A total of 28 male rats were divided into four groups: control, ethanol, ethanol-losartan 1&#xa0;mg/kg, and ethanol-losartan 3&#xa0;mg/kg. Over 42 days, the ethanol group received 20% ethanol in their drinking water, while losartan was administered intraperitoneally at doses of 1&#xa0;mg/kg and 3&#xa0;mg/kg to the treatment groups.The results demonstrated that losartan significantly reduced oxidative stress markers, evidenced by decreased levels of malondialdehyde and increased total thiol levels in renal tissues. Furthermore, losartan treatment enhanced the activity of key antioxidant enzymes, including superoxide dismutase and catalase. Inflammatory markers, specifically interleukin-6, were also significantly lower in losartan-treated groups compared to the ethanol group. Additionally, losartan improved renal function as indicated by reductions in blood urea nitrogen, creatinine, and uric acid levels. The higher dose of losartan (3&#xa0;mg/kg) demonstrated more pronounced effects in mitigating oxidative stress and improving renal parameters. Losartan exhibited significant protective effects against ethanol-induced renal injury, likely due to its antioxidant and anti-inflammatory properties. These findings suggest that losartan may serve as a potential therapeutic agent for managing alcohol-related kidney damage, warranting further investigation into its mechanisms of action and clinical applications.</p>

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Losartan Protects Against Ethanol-Induced Kidney Dysfunction in Male Wistar Rats: Insights into Antioxidant and Anti-inflammatory Therapies

  • 期刊论文

  • 发表日期：

    2025年9月24日

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  • Fateme Razazpour,
  • Mahdiyeh Hedayati-Moghadam,
  • Fatemeh Seyedi,
  • Yousef Baghcheghi

摘要

Chronic ethanol consumption poses significant threats to renal health, leading to oxidative stress and inflammation, which can exacerbate kidney dysfunction. The aim of this study was to investigate the protective effects of losartan, an angiotensin II receptor blocker, against ethanol-induced renal damage in male Wistar rats. A total of 28 male rats were divided into four groups: control, ethanol, ethanol-losartan 1 mg/kg, and ethanol-losartan 3 mg/kg. Over 42 days, the ethanol group received 20% ethanol in their drinking water, while losartan was administered intraperitoneally at doses of 1 mg/kg and 3 mg/kg to the treatment groups.The results demonstrated that losartan significantly reduced oxidative stress markers, evidenced by decreased levels of malondialdehyde and increased total thiol levels in renal tissues. Furthermore, losartan treatment enhanced the activity of key antioxidant enzymes, including superoxide dismutase and catalase. Inflammatory markers, specifically interleukin-6, were also significantly lower in losartan-treated groups compared to the ethanol group. Additionally, losartan improved renal function as indicated by reductions in blood urea nitrogen, creatinine, and uric acid levels. The higher dose of losartan (3 mg/kg) demonstrated more pronounced effects in mitigating oxidative stress and improving renal parameters. Losartan exhibited significant protective effects against ethanol-induced renal injury, likely due to its antioxidant and anti-inflammatory properties. These findings suggest that losartan may serve as a potential therapeutic agent for managing alcohol-related kidney damage, warranting further investigation into its mechanisms of action and clinical applications.