<p>Additive manufacturing offers a cost-effective alternative to traditional methods, enabling faster production of intricate structures. This study investigated the tensile performance of PLA-based 3D printed material with both 3D-printed and conventionally drilled holes. A total of 18 specimens are fabricated with varying infill patterns, infill densities and raster orientations, where nine specimens are printed with predefined 4-mm holes while the remaining are drilled conventionally with the same size. Statistical analysis using an L₉ orthogonal array showed that 3D printed hole specimens have superior tensile strength. The optimal tensile strength is achieved with a concentric pattern having 100% infill density with 0° raster orientation, regardless of whether the holes are printed or drilled. Drilled-hole specimens attained a higher tensile strength of 20.8&#xa0;MPa, while printed-hole specimens reached 22.3&#xa0;MPa under the same parametric combination of a concentric pattern with 100% infill density and 0º raster orientation, demonstrating the enhanced tensile strength provided by directly printed specimen with an improvement of approximately 7.21% compared to those with conventionally drilled holes. The main effects plot validated that the infill pattern has the highest influence on tensile strength, with concentric infill providing the maximum UTS due to its effective stress distribution around the hole. Infill density and raster orientation also improve strength when the infill density increase from 80 to 100% and raster orientation decreases from 90 to 0°. Based on the ANOVA results, the infill pattern show a major impact on tensile strength, influencing 85.07% of specimens with 3D-printed holes and 92.31% with conventionally drilled holes.</p>