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<p>Bone tissue engineering presents a promising method for regenerating bone tissue through porous scaffold structures. This research proposes a new multi-response optimization approach by integrating Taguchi-Based VIKOR (VIekriterijumsko Kompromisno Rangiranje) and Taguchi-Based TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) methods to optimize the parameters of fused deposition modeling (FDM) for fabricating gyroid scaffolds using a PLA/MgTiO<sub>3</sub> composite, designed for biomedical applications. The study aims to enhance scaffold performance by improving mechanical strength, bioactivity, and energy absorption while ensuring efficient production. The composite filaments were prepared through a modified mixing method to achieve the desired properties. The optimization framework evaluates key parameters of the FDM process, including layer height (0.10–0.20&#xa0;mm), extrusion temperature (205–220&#xa0;°C), and printing speed (25–50&#xa0;mm/s). Scaffold performance was assessed based on compression strength, Young’s modulus, specific energy absorption (SEA), and printing time. The optimal parameter configuration-layer height of 0.10&#xa0;mm, extrusion temperature of 205&#xa0;°C, and printing speed of 25&#xa0;mm/s resulted in a compression strength of 45.70&#xa0;MPa, Young’s modulus of 0.47 GPa, SEA of 0.50&#xa0;J/kg, and a printing time of 59&#xa0;min. The findings demonstrate that lower layer heights and slower speeds significantly enhance mechanical properties but increase production time. This study provides an effective methodology for optimizing multi-response FDM processes to fabricate application-specific scaffolds for biomedical use.</p>

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Multi-response optimization of FDM parameters for high-performance PLA/MgTiO3 TPMS gyroid scaffolds: a Taguchi-based VIKOR–TOPSIS approach for biomedical applications

  • 期刊论文

  • 发表日期：

    2025年5月5日

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  • P. Vicky Kumar,
  • Anil Kumar Birru,
  • Nelson Muthu

摘要

Bone tissue engineering presents a promising method for regenerating bone tissue through porous scaffold structures. This research proposes a new multi-response optimization approach by integrating Taguchi-Based VIKOR (VIekriterijumsko Kompromisno Rangiranje) and Taguchi-Based TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) methods to optimize the parameters of fused deposition modeling (FDM) for fabricating gyroid scaffolds using a PLA/MgTiO3 composite, designed for biomedical applications. The study aims to enhance scaffold performance by improving mechanical strength, bioactivity, and energy absorption while ensuring efficient production. The composite filaments were prepared through a modified mixing method to achieve the desired properties. The optimization framework evaluates key parameters of the FDM process, including layer height (0.10–0.20 mm), extrusion temperature (205–220 °C), and printing speed (25–50 mm/s). Scaffold performance was assessed based on compression strength, Young’s modulus, specific energy absorption (SEA), and printing time. The optimal parameter configuration-layer height of 0.10 mm, extrusion temperature of 205 °C, and printing speed of 25 mm/s resulted in a compression strength of 45.70 MPa, Young’s modulus of 0.47 GPa, SEA of 0.50 J/kg, and a printing time of 59 min. The findings demonstrate that lower layer heights and slower speeds significantly enhance mechanical properties but increase production time. This study provides an effective methodology for optimizing multi-response FDM processes to fabricate application-specific scaffolds for biomedical use.