<p>Four-dimensional (4D) printing provides the route for the incorporation of transformation information into 3D-printed structures which allows them to change shape, characteristics, or functionality with time. To address the issue of stent-related thrombosis and in-stent restenosis, self-expandable biodegradable vascular stents were created using 4D printing using a shape memory polymer composite containing bioactive glass (BG) powder and polylactic acid (PLA). The printed stent is capable of being crimped into a temporary form with reduced diameter, making it easier to implant. The dimensional study demonstrated the deviation in dimensions from the CAD model showing manufacturing precision. The mechanical properties of the stents are investigated by axial compression and three-point bending tests. The findings demonstrated that stents possessed sufficient mechanical characteristics to effectively carry out the essential functions within the human coronary system. With a significant fixity and a recovery ratio of 85 and 90%, the printed stent demonstrated shape memory capabilities and was able to retain its temporary shape while being stored at ambient temperature. Finite element analysis was used to calculate the longitudinal contraction or radical expansion under operating conditions and compared with the balloon expanded vascular stent. In vitro biological testing showed that the stents were biocompatible, hemocompatible, and thrombosis-resistant. The integration of self-expansion and personalized 3D printing in the creation of vascular stents offers a promising alternative for the treatment of cardiovascular diseases. This approach has the potential to address the limitations of balloon angioplasty.</p>