<p>Recent advances in additive manufacturing (AM) have transformed manufacturing and engineering. Direct energy deposition with arc and wire (DED-Arc) stands out due to its high deposition rates, cost-effectiveness, material efficiency, and environmental benefits. DED-Arc is ideal for producing large and medium-complexity metal components, distinguishing it from traditional and other AM methods; however, limited research has been conducted on thick-walled parts compared to single-walled ones. This study investigates the microstructure and anisotropy of mechanical properties in 316L stainless steel parts manufactured using DED-Arc with various deposition strategies. Through parameter optimization, this research achieves the successful fabrication of large-walled components, highlighting the crucial role of deposition parameters in their production. Analysis of X-ray diffraction (XRD) peaks related to the (111) and (200) planes of the austenite phase reveals the development of crystallographic texture post-weld, further supported by electron backscatter diffraction (EBSD) analyses indicating a pronounced presence of texture. Scanning Electron Microscope (SEM) analyses identify distinct ferrite phase morphologies in different component regions. Mechanical testing suggests a bias toward anisotropic behavior in DED-Arc materials, with 45° overlap angle samples demonstrating slightly superior mechanical properties. Consistent microhardness along the build direction underscores the reliability of the deposition strategy. Residual stresses were investigated using XRD on the outer surfaces of all DED-Arc samples, and profiles analyzed away from the substrate show only compressive stresses. Changing the overlap angle changes the texture intensity of the parts.</p>