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<p>Breast cancer (BC) remains one of the most prevalent and lethal malignancies worldwide. Despite significant improvements in patient survival over recent decades—largely attributed to advances in screening programs and adjuvant systemic therapies, including chemotherapy and hormone therapy—metastatic recurrence continues to be a major cause of mortality. Proteomics has emerged as a transformative tool in biomedical research, offering new opportunities to identify therapeutic targets and discover novel pathological biomarkers. With its capacity for large-scale, high-throughput analysis, proteomics enables the detection, quantification, and functional characterization of low-abundance proteins. Recent studies emphasize the integration of proteomics with genomics as a crucial step toward the molecular characterization of distinct breast cancer subtypes and the development of innovative therapeutic strategies. The exceptional sensitivity and specificity of proteomic technologies for detecting selected biomarkers underscore their potential for the early diagnosis of breast cancer. This review aims to provide a comprehensive overview of recent advances in the application of proteomics to breast cancer diagnosis and treatment. By synthesizing findings from high-impact studies, it seeks to highlight the current progress in proteomic technologies and their transformative potential in oncology.</p>

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Advances in Proteomics for Breast Cancer: Bridging Biomarker Discovery and Clinical Application

  • 期刊论文

  • 发表日期：

    2026年6月17日

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  • Farhood Ghazi,
  • Ahmad Mobed,
  • Vahid Alivirdiloo,
  • Mobasher Hajiabbasi,
  • Homa Kohandel Gargari,
  • Iraj Alipourfard,
  • Mahsa Alem,
  • Fatemeh Rahimi,
  • Akram Firouzi Amandi,
  • Narjes Habibimoghadam,
  • Mehdi Dadashpour

摘要

Breast cancer (BC) remains one of the most prevalent and lethal malignancies worldwide. Despite significant improvements in patient survival over recent decades—largely attributed to advances in screening programs and adjuvant systemic therapies, including chemotherapy and hormone therapy—metastatic recurrence continues to be a major cause of mortality. Proteomics has emerged as a transformative tool in biomedical research, offering new opportunities to identify therapeutic targets and discover novel pathological biomarkers. With its capacity for large-scale, high-throughput analysis, proteomics enables the detection, quantification, and functional characterization of low-abundance proteins. Recent studies emphasize the integration of proteomics with genomics as a crucial step toward the molecular characterization of distinct breast cancer subtypes and the development of innovative therapeutic strategies. The exceptional sensitivity and specificity of proteomic technologies for detecting selected biomarkers underscore their potential for the early diagnosis of breast cancer. This review aims to provide a comprehensive overview of recent advances in the application of proteomics to breast cancer diagnosis and treatment. By synthesizing findings from high-impact studies, it seeks to highlight the current progress in proteomic technologies and their transformative potential in oncology.