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Objective <p>Ovarian metastasis (OM) of breast carcinoma is a rare event. Diagnosis of OM is challenging and in the majority of cases, the patients are asymptomatic and diagnosis is made incidentally.</p> Methods <p>Patient case data was retrospectively retrieved from the institution’s electronic medical record system.</p> Results <p>We herein report four cases of OM from breast cancer in which the patients were diagnosed with breast cancer with the involvement of genetic factors. Bilateral salpingo-oophorectomy is a prophylactic surgery done in a known case of carcinoma of the breast with BRCA 1, and BRCA 2 mutations, as these patients are prone to develop serous carcinoma in fallopian tubes and ovaries. All the cases have showed poorly differentiated carcinoma of the ovary after histopathological examination in prophylactic surgeries. On immunohistochemistry, these lesions proved to be metastatic deposits of invasive carcinoma of the breast.</p> Conclusion <p>To avoid delayed diagnosis in such patients - clinical history, macroscopic features, awareness of this possibility, continued surveillance of ovaries, and considering immunohistochemistry can play a key role in distinguishing between primary ovarian tumors and OM.</p>

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Metastatic Deposit of Invasive Breast Carcinoma in Ovary – A Rare Case Series from A Single Institute

  • 期刊论文

  • 发表日期：

    2025年12月19日

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  • Sucheta Gandhe,
  • Yogesh Pawar,
  • Aditya Adhav,
  • Yasam Venkata Ramesh,
  • Raj Nagarkar

摘要

Objective

Ovarian metastasis (OM) of breast carcinoma is a rare event. Diagnosis of OM is challenging and in the majority of cases, the patients are asymptomatic and diagnosis is made incidentally.

Methods

Patient case data was retrospectively retrieved from the institution’s electronic medical record system.

Results

We herein report four cases of OM from breast cancer in which the patients were diagnosed with breast cancer with the involvement of genetic factors. Bilateral salpingo-oophorectomy is a prophylactic surgery done in a known case of carcinoma of the breast with BRCA 1, and BRCA 2 mutations, as these patients are prone to develop serous carcinoma in fallopian tubes and ovaries. All the cases have showed poorly differentiated carcinoma of the ovary after histopathological examination in prophylactic surgeries. On immunohistochemistry, these lesions proved to be metastatic deposits of invasive carcinoma of the breast.

Conclusion

To avoid delayed diagnosis in such patients - clinical history, macroscopic features, awareness of this possibility, continued surveillance of ovaries, and considering immunohistochemistry can play a key role in distinguishing between primary ovarian tumors and OM.