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Introduction <p>Primary ovarian non-Hodgkin’s lymphoma (PONHL) is a rare condition, accounting for 0.5% of NHLs and 1.5% of ovarian neoplasms. The most common type is diffuse large B-cell lymphoma (DLBCL). Commonly presents with abdominal pain and enlarging pelvic mass. Diagnosis before surgery can be challenging due to symptom overlap. This article describes the cases of primary non-Hodgkin lymphomas of the ovary reported at our center along with review of literature summarizing prior published cases.</p> Methods <p>This retrospective study was carried out at the Department of Onco Pathology, MPMMCC, Varanasi, over a period of 5&#xa0;years, from January 2019 to December 2024. The cases of PONHL were identified, and the clinic pathologic characteristics, immunohistochemical results, treatment approaches, and outcomes of these cases are compiled and summarized.</p> Results <p>The patients, aged 14–45&#xa0;years with a mean age of 25, presented with abdominal pain and swelling, resembling epithelial malignancy. After a thorough immunohistochemistry panel, diagnosis of PONHL was confirmed. Among three cases, one was diagnosed diffuse large B-cell lymphoma, one precursor B-lymphoblastic lymphoma, and one Burkitt lymphoma. Two patients succumbed to the disease, while one remains alive and disease-free till date.</p> Conclusion <p>Primary ovarian non-Hodgkin lymphoma (PONHL) is a rare condition, predominantly presenting with a B-cell phenotype, with an incidence of 0.2% observed at our institution. Due to its nonspecific pelvic symptoms, it is frequently misdiagnosed. Therefore, a definitive diagnosis relies on biopsy and immunohistochemical analysis. Chemotherapy remains the mainstay of treatment. Although it is typically aggressive, early-stage diagnosis can lead to a more favorable prognosis.</p>

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“When Ovarian Malignancy Isn’t What It seems”: Primary Ovarian Lymphomas Mimicking Epithelial Cancer—A Single-Institution Experience with a Summary of Prior Published Cases

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月6日

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  • Ipsita Dhal,
  • Isha Makker,
  • Himani Rai,
  • Shreya Shukla,
  • Anil Singh,
  • Roma Jethani

摘要

Introduction

Primary ovarian non-Hodgkin’s lymphoma (PONHL) is a rare condition, accounting for 0.5% of NHLs and 1.5% of ovarian neoplasms. The most common type is diffuse large B-cell lymphoma (DLBCL). Commonly presents with abdominal pain and enlarging pelvic mass. Diagnosis before surgery can be challenging due to symptom overlap. This article describes the cases of primary non-Hodgkin lymphomas of the ovary reported at our center along with review of literature summarizing prior published cases.

Methods

This retrospective study was carried out at the Department of Onco Pathology, MPMMCC, Varanasi, over a period of 5 years, from January 2019 to December 2024. The cases of PONHL were identified, and the clinic pathologic characteristics, immunohistochemical results, treatment approaches, and outcomes of these cases are compiled and summarized.

Results

The patients, aged 14–45 years with a mean age of 25, presented with abdominal pain and swelling, resembling epithelial malignancy. After a thorough immunohistochemistry panel, diagnosis of PONHL was confirmed. Among three cases, one was diagnosed diffuse large B-cell lymphoma, one precursor B-lymphoblastic lymphoma, and one Burkitt lymphoma. Two patients succumbed to the disease, while one remains alive and disease-free till date.

Conclusion

Primary ovarian non-Hodgkin lymphoma (PONHL) is a rare condition, predominantly presenting with a B-cell phenotype, with an incidence of 0.2% observed at our institution. Due to its nonspecific pelvic symptoms, it is frequently misdiagnosed. Therefore, a definitive diagnosis relies on biopsy and immunohistochemical analysis. Chemotherapy remains the mainstay of treatment. Although it is typically aggressive, early-stage diagnosis can lead to a more favorable prognosis.