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Objective <p>The study aimed to evaluate pretreatment neutrophil-to-lymphocyte ratio (NLR) and prognostic nutrition index (PNI) as predictive factors for predicting clinical outcomes after definitive chemoradiotherapy for cervical cancer.</p> Methods <p>Patients with cervical cancer who received definitive chemoradiotherapy between 2017 and 2022 were retrospectively investigated. The pretreatment PNI and NLR were measured, and survival outcomes were evaluated.</p> Results <p>We retrospectively analyzed 74 patients and were divided into a high NLR and PNI group (NLR ≥ 2.8 and PNI ≥ 49.5) and a low NLR and PNI group (NLR &lt; 2.8 or PNI &lt; 49.5). Patients with low NLR had higher DFS than patients in the other groups (2-year DFS, low NLR vs. high NLR, 81.6 vs. 60.2%, <i>P</i> &lt; 0.05; 5-year DFS, low NLR vs. high NLR, 57.0 vs. 48.2%, <i>P</i> &lt; 0.05). We showed that patients with a low PNI had shorter DFS (low PNI vs. high PNI, 2-year DFS, 60.8% vs. 79.0%, <i>P</i> &lt; 0.05; 5-year DFS, 36.5% vs. 58.5%, <i>P</i> &lt; 0.05).</p> Conclusion <p>Pretreatment PNI values and NLR values can be used as simple and feasible predictors of survival outcomes for patients treated with chemoradiotherapy for cervical cancer.</p>

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Neutrophil–Lymphocyte Ratio and Prognostic Nutritional Index Predict Prognosis for Definitive Chemoradiotherapy in Cervical Cancer

  • 期刊论文

  • 发表日期：

    2025年6月27日

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  • Rumeysa Colak,
  • Caner Kapar,
  • Ezgi Degerli,
  • Mesut Yilmaz

摘要

Objective

The study aimed to evaluate pretreatment neutrophil-to-lymphocyte ratio (NLR) and prognostic nutrition index (PNI) as predictive factors for predicting clinical outcomes after definitive chemoradiotherapy for cervical cancer.

Methods

Patients with cervical cancer who received definitive chemoradiotherapy between 2017 and 2022 were retrospectively investigated. The pretreatment PNI and NLR were measured, and survival outcomes were evaluated.

Results

We retrospectively analyzed 74 patients and were divided into a high NLR and PNI group (NLR ≥ 2.8 and PNI ≥ 49.5) and a low NLR and PNI group (NLR < 2.8 or PNI < 49.5). Patients with low NLR had higher DFS than patients in the other groups (2-year DFS, low NLR vs. high NLR, 81.6 vs. 60.2%, P < 0.05; 5-year DFS, low NLR vs. high NLR, 57.0 vs. 48.2%, P < 0.05). We showed that patients with a low PNI had shorter DFS (low PNI vs. high PNI, 2-year DFS, 60.8% vs. 79.0%, P < 0.05; 5-year DFS, 36.5% vs. 58.5%, P < 0.05).

Conclusion

Pretreatment PNI values and NLR values can be used as simple and feasible predictors of survival outcomes for patients treated with chemoradiotherapy for cervical cancer.