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Purpose <p>This study aimed to document institutional Standard Operating Procedures (SOPs) and evaluate their effect on perioperative outcomes in patients undergoing Cytoreductive Surgery (CRS) with or without Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for ovarian cancer.</p> Methods <p>A prospective analysis of 200 patients was conducted, with 100 undergoing CRS + HIPEC and 100 undergoing CRS alone. SOPs were developed for preoperative, intraoperative, and postoperative care. The primary outcomes included operative time, blood loss, postoperative stay, time to oral feeding, and complications. Statistical analysis was performed using SPSS version 22.</p> Results <p>SOPs standardized perioperative management, including early mobilization, careful fluid management, and multidisciplinary decision-making, optimizing outcomes for both groups. The CRS + HIPEC group had significantly longer operative times (7.2&#xa0;h vs. 4.5&#xa0;h, <i>p</i> &lt; 0.05) and higher blood loss (700&#xa0;ml vs. 400&#xa0;ml, <i>p</i> &lt; 0.05), reflecting the complexity of these procedures. However, postoperative hospital stays (6.2 vs. 6.3&#xa0;days) and time to oral feeding (3.8&#xa0;days for both) were similar across groups. Morbidity rates, including pleural effusion and wound infections, did not differ significantly (<i>p</i> &gt; 0.05).</p> Conclusion <p>Implementing SOPs enhanced perioperative outcomes in patients undergoing CRS + HIPEC. Despite the increased complexity and longer operative times in CRS + HIPEC; the hospital stay, morbidity, and recovery times were comparable to CRS alone, emphasizing the value of structured SOPs in minimizing risk and improving patient recovery.</p>

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Impact of Institutional Standard Operating Procedures on Perioperative Outcomes in Patients Undergoing Cytoreductive Surgery with and without HIPEC: A Comparative Analysis in Ovary Cancer

  • 期刊论文

  • 发表日期：

    2025年2月7日

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  • Swati Shah,
  • Harsh Shah,
  • Nisarg Patel,
  • Akash Shah,
  • Rushit Shah,
  • Bankim Shah,
  • Bimal Chhaya,
  • Ankit Chauhan,
  • Jay Kothari

摘要

Purpose

This study aimed to document institutional Standard Operating Procedures (SOPs) and evaluate their effect on perioperative outcomes in patients undergoing Cytoreductive Surgery (CRS) with or without Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for ovarian cancer.

Methods

A prospective analysis of 200 patients was conducted, with 100 undergoing CRS + HIPEC and 100 undergoing CRS alone. SOPs were developed for preoperative, intraoperative, and postoperative care. The primary outcomes included operative time, blood loss, postoperative stay, time to oral feeding, and complications. Statistical analysis was performed using SPSS version 22.

Results

SOPs standardized perioperative management, including early mobilization, careful fluid management, and multidisciplinary decision-making, optimizing outcomes for both groups. The CRS + HIPEC group had significantly longer operative times (7.2 h vs. 4.5 h, p < 0.05) and higher blood loss (700 ml vs. 400 ml, p < 0.05), reflecting the complexity of these procedures. However, postoperative hospital stays (6.2 vs. 6.3 days) and time to oral feeding (3.8 days for both) were similar across groups. Morbidity rates, including pleural effusion and wound infections, did not differ significantly (p > 0.05).

Conclusion

Implementing SOPs enhanced perioperative outcomes in patients undergoing CRS + HIPEC. Despite the increased complexity and longer operative times in CRS + HIPEC; the hospital stay, morbidity, and recovery times were comparable to CRS alone, emphasizing the value of structured SOPs in minimizing risk and improving patient recovery.