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<p>Retinal disease treatment underwent a transformation with intravitreal injections because these procedures execute therapeutic agents like anti-VEGF drugs, corticosteroids and antibiotics straight into vitreous cavity. Post-intravitreal complications including endophthalmitis, intraocular inflammation, elevated intraocular pressure (IOP) and retinal toxicity continue presenting substantial difficulties that deteriorate patient results. The development of silk fibroin and sericin as novel polymeric biomaterials has shown revolutionary potential for resolving existing limitations and emerging as promising ocular drug delivery materials. These natural proteins obtained from <i>Bombyx mori</i>cocoons have shown excellent biocompatibility, biodegradability and adjustable mechanical properties. The development of silk-based drug delivery systems like nanoparticles, microparticles, hydrogels and implants reduce the need for frequent injections and improves drug performance and reduces side effects. The combination of silk’s antioxidant properties and its anti-inflammatory character strengthen its therapeutic applications in ocular treatments. This study shows how these silk-based materials are increasingly used for post-intravitreal complication management and the way they tackle problems related to rapid drug clearance and drug insolubility in addition to tissue toxicities. Silk-based systems demonstrate distinct capabilities which this review demonstrates can enhance patient medication adherence while minimizing adverse effects to create superior ocular therapies for retinal diseases treatment.&#xa0;Silk-based polymeric materials are emerging as a promising solution fordelivering therapeutics after complications from intravitreal injections, such as inflammation or&#xa0;infection in the eye. These materials, especially silk fibroin, are biocompatible, mechanically&#xa0;strong, and can be engineered to release drugs in a controlled and sustained manner, which&#xa0;helps reduce the need for repeated injections and improves treatment outcomes. Silk-based&#xa0;systems are being explored for treating conditions like glaucoma, diabetic retinopathy, and other&#xa0;retinal diseases, where sustained and targeted drug delivery is critical. These materials can help&#xa0;protect the eye from further damage, support tissue healing, and deliver drugs directly to the&#xa0;affected area, improving both safety and effectiveness compared to traditional&#xa0;treatments. Ongoing research aims to further optimize silk-based polymers for use in advanced&#xa0;ocular therapies, including smart, stimuli-responsive drug delivery systems. As these&#xa0;technologies develop, silk-based materials are expected to play an increasingly important role in&#xa0;improving outcomes for patients with post-intravitreal complications and other challenging eye&#xa0;conditions.</p> Graphical Abstract <p>Schematic diagram showing the complete summary of silk-based novel material in developing of DDS for targeting post-intravitreal complications (Created with BioRender.com)</p>

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Emerging Utility of Silk-based Polymeric Materials in Delivering Therapeutics for Post Intravitreal Complication: A Review

  • 期刊论文

  • 发表日期：

    2026年1月28日

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  • Naureen Afrose,
  • Rideb Chakraborty,
  • Biswajit Basu,
  • Rajdip Goswami,
  • Sudarshan Singh,
  • Bhupendra Prajapati

摘要

Retinal disease treatment underwent a transformation with intravitreal injections because these procedures execute therapeutic agents like anti-VEGF drugs, corticosteroids and antibiotics straight into vitreous cavity. Post-intravitreal complications including endophthalmitis, intraocular inflammation, elevated intraocular pressure (IOP) and retinal toxicity continue presenting substantial difficulties that deteriorate patient results. The development of silk fibroin and sericin as novel polymeric biomaterials has shown revolutionary potential for resolving existing limitations and emerging as promising ocular drug delivery materials. These natural proteins obtained from Bombyx moricocoons have shown excellent biocompatibility, biodegradability and adjustable mechanical properties. The development of silk-based drug delivery systems like nanoparticles, microparticles, hydrogels and implants reduce the need for frequent injections and improves drug performance and reduces side effects. The combination of silk’s antioxidant properties and its anti-inflammatory character strengthen its therapeutic applications in ocular treatments. This study shows how these silk-based materials are increasingly used for post-intravitreal complication management and the way they tackle problems related to rapid drug clearance and drug insolubility in addition to tissue toxicities. Silk-based systems demonstrate distinct capabilities which this review demonstrates can enhance patient medication adherence while minimizing adverse effects to create superior ocular therapies for retinal diseases treatment. Silk-based polymeric materials are emerging as a promising solution fordelivering therapeutics after complications from intravitreal injections, such as inflammation or infection in the eye. These materials, especially silk fibroin, are biocompatible, mechanically strong, and can be engineered to release drugs in a controlled and sustained manner, which helps reduce the need for repeated injections and improves treatment outcomes. Silk-based systems are being explored for treating conditions like glaucoma, diabetic retinopathy, and other retinal diseases, where sustained and targeted drug delivery is critical. These materials can help protect the eye from further damage, support tissue healing, and deliver drugs directly to the affected area, improving both safety and effectiveness compared to traditional treatments. Ongoing research aims to further optimize silk-based polymers for use in advanced ocular therapies, including smart, stimuli-responsive drug delivery systems. As these technologies develop, silk-based materials are expected to play an increasingly important role in improving outcomes for patients with post-intravitreal complications and other challenging eye conditions.

Graphical Abstract

Schematic diagram showing the complete summary of silk-based novel material in developing of DDS for targeting post-intravitreal complications (Created with BioRender.com)