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<p>Wound healing is a complex and dynamic biological process involving hemostasis, inflammation, proliferation, and remodeling. Effective wound care is essential to prevent infection, reduce scarring, and improve patient outcomes and quality of life. In recent years, biopolymers and medicinal plants have attracted significant attention due to their intrinsic biocompatibility, biodegradability, and diverse pharmacological activities. This comprehensive literature review explores the therapeutic potential of biopolymers and selected medicinal plants, with particular emphasis on their roles in promoting tissue regeneration. A comprehensive literature review was conducted to evaluate the wound healing efficacy of biopolymers and medicinal plants. Relevant peer-reviewed articles were identified through systematic searches of accessible databases. Selection criteria included experimental, preclinical, and clinical studies that reported anti-inflammatory, antimicrobial, antioxidant, or regenerative properties of these materials. Biopolymers, such as chitosan, alginate, carrageenan, and hyaluronic acid, support tissue repair, reduce inflammation, and act as drug delivery matrices. Medicinal plants including <i>Arctium lappa</i> L., <i>Centella asiatica</i> (L.) Urban, <i>Clitoria ternatea</i> L., <i>Melastoma malabathricum</i> L., <i>Filicium decipiens</i> (Wight &amp; Arn.) Thwaites, and <i>Curcuma longa</i> L. exhibited antimicrobial, antioxidant, and anti-inflammatory activities. The synergistic use of these compounds offers a promising, sustainable, and cost-effective strategy for treating acute and chronic wounds. Biopolymer-phytochemical combinations are emerging as potential strategies in wound management, with relevance to the growing public health challenge of non-healing wounds among aging populations and individuals with chronic conditions. Future work should focus on clinical validation, scalable formulation technologies, and integration into personalized wound care approaches. Lay Summary. This review explores how natural materials like plant extracts and biopolymers can help heal wounds more effectively. Many of these substances not only fight germs and reduce inflammation but also help skin grow back faster. Using them together may offer a safer, more affordable way to treat cuts, burns, and chronic wounds, especially in older adults or people with diabetes.</p>

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Biopolymers and Medicinal Plants in Wound Healing: a Comprehensive Literature Review of Advances in Tissue Regeneration and Translational Applications

  • 期刊论文

  • 发表日期：

    2025年12月2日

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  • Felix Tye Kai Ler,
  • Marwan Abdelmahmoud Abdelkarim Maki,
  • Mogana S. Rajagopal,
  • Karthikeyan Ramadoss,
  • Palanirajan Vijayaraj Kumar

摘要

Wound healing is a complex and dynamic biological process involving hemostasis, inflammation, proliferation, and remodeling. Effective wound care is essential to prevent infection, reduce scarring, and improve patient outcomes and quality of life. In recent years, biopolymers and medicinal plants have attracted significant attention due to their intrinsic biocompatibility, biodegradability, and diverse pharmacological activities. This comprehensive literature review explores the therapeutic potential of biopolymers and selected medicinal plants, with particular emphasis on their roles in promoting tissue regeneration. A comprehensive literature review was conducted to evaluate the wound healing efficacy of biopolymers and medicinal plants. Relevant peer-reviewed articles were identified through systematic searches of accessible databases. Selection criteria included experimental, preclinical, and clinical studies that reported anti-inflammatory, antimicrobial, antioxidant, or regenerative properties of these materials. Biopolymers, such as chitosan, alginate, carrageenan, and hyaluronic acid, support tissue repair, reduce inflammation, and act as drug delivery matrices. Medicinal plants including Arctium lappa L., Centella asiatica (L.) Urban, Clitoria ternatea L., Melastoma malabathricum L., Filicium decipiens (Wight & Arn.) Thwaites, and Curcuma longa L. exhibited antimicrobial, antioxidant, and anti-inflammatory activities. The synergistic use of these compounds offers a promising, sustainable, and cost-effective strategy for treating acute and chronic wounds. Biopolymer-phytochemical combinations are emerging as potential strategies in wound management, with relevance to the growing public health challenge of non-healing wounds among aging populations and individuals with chronic conditions. Future work should focus on clinical validation, scalable formulation technologies, and integration into personalized wound care approaches. Lay Summary. This review explores how natural materials like plant extracts and biopolymers can help heal wounds more effectively. Many of these substances not only fight germs and reduce inflammation but also help skin grow back faster. Using them together may offer a safer, more affordable way to treat cuts, burns, and chronic wounds, especially in older adults or people with diabetes.