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Abstract <p>Influenza virus is a persistent source of morbidity and moribundity, and effective disease control requires ever-evolving effective vaccines. In this work, we evaluate the safety and biocompatibility of two novel polymeric particle-based influenza vaccines. Mice were immunized either intranasally or subcutaneously with these two formulations and examined at 1 h, 1 day, and 14 days post-immunization for histopathology in liver, kidneys, and lungs and serum biomarker analysis. Mice that received an intranasal vaccination were also observed for pulmonary disruption via whole body plethysmography. Examination of tissues post-immunization found only limited inflammation, with no difference observed in plethysmography measurements and no serum biomarkers (e.g., AST, AlkPhos) indicating tissue damage. Collectively, these data support the conclusion that these polymeric particle-based influenza vaccine formulations were well tolerated by the animals and did not induce any adverse side effects.</p> Lay summary <p>Particle-based influenza vaccines were safety tolerated by mice and did not induce any adverse side effects.</p>

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Safety and Biocompatibility of a Spray-Dried Influenza Microparticle Vaccine in Mice

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月15日

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  • A. C. Siddoway,
  • D. Verhoeven,
  • T. A. Harm,
  • M. J. Wannemuehler,
  • S. K. Mallapragada,
  • B. Narasimhan

摘要

Abstract

Influenza virus is a persistent source of morbidity and moribundity, and effective disease control requires ever-evolving effective vaccines. In this work, we evaluate the safety and biocompatibility of two novel polymeric particle-based influenza vaccines. Mice were immunized either intranasally or subcutaneously with these two formulations and examined at 1 h, 1 day, and 14 days post-immunization for histopathology in liver, kidneys, and lungs and serum biomarker analysis. Mice that received an intranasal vaccination were also observed for pulmonary disruption via whole body plethysmography. Examination of tissues post-immunization found only limited inflammation, with no difference observed in plethysmography measurements and no serum biomarkers (e.g., AST, AlkPhos) indicating tissue damage. Collectively, these data support the conclusion that these polymeric particle-based influenza vaccine formulations were well tolerated by the animals and did not induce any adverse side effects.

Lay summary

Particle-based influenza vaccines were safety tolerated by mice and did not induce any adverse side effects.