Purpose <p>Inflammatory conditions, such as edema, are characterized by fluid accumulation and tissue damage, requiring effective therapeutic strategies. Nanoemulsion-based therapeutics offer a promising solution by enhancing drug solubility, stability, and targeted delivery. This research explores recent advancements in nanoemulsion formulations, emphasizing their physicochemical properties, stability, and potential for efficient anti-inflammatory drug delivery.</p> Methods <p>A detailed review of preclinical and clinical studies was conducted, analyzing the efficacy of nanoemulsions in managing inflammation and edema through various administration routes, including topical, oral, and intravenous. Emphasis was placed on novel approaches like stimuli-responsive and ligand-targeted nanoemulsions, as well as their role in enhancing drug delivery.</p> Results <p>Nanoemulsions, with nanometer-sized droplets, demonstrated enhanced drug solubility, bioavailability, and controlled release. Preclinical studies confirmed their effectiveness in delivering hydrophobic anti-inflammatory agents, ensuring localized action and minimizing systemic side effects. Novel formulations showed improved specificity and therapeutic outcomes, while reduced dosing frequency enhanced patient compliance.</p> Conclusion <p>Nanoemulsions serve as a versatile and effective platform for anti-inflammatory therapies, offering controlled release, targeted delivery, and reduced side effects. Recent advancements highlight their transformative potential in nanomedicine for treating inflammation and edema.</p> <p>Lay Summary.</p> <p>Nanoemulsions are advanced drug delivery systems that help treat swelling and inflammation effectively. They improve how drugs work, reduce side effects, and make treatments easier for patients, showing great promise for future medical applications.</p> Graphical Abstract <p></p>