Purpose <p>Diabetic wounds (DWs) represent a major global health burden and managing them is fraught with difficulties. Bio-polymeric compositions have drawn interest as potentially effective treatment strategies for DW healing.</p> Method <p>The potential of graft/engineered biopolymers in the development of nanofibers (NFs) intended to improve wound care for diabetes patients is investigated and reported in this paper.</p> Results <p>Natural sources of biomaterials give beneficial qualities to graft/engineered biopolymers, including biocompatibility, biodegradability, and the capacity to replicate the extracellular matrix, which makes them appropriate for cutting-edge wound care applications. The review highlights the efficiency of electrospinning and other manufacturing processes involved in the development of NFs, highlighting their ability to produce porous structures and large surface areas that facilitate gas exchange and moisture retention. Additionally, a comprehensive evaluation of recent developments in graft-biopolymer composition and manufacturing optimization is presented to enhance therapeutic results in DW healing. Along with addressing issues like scalability, regulatory barriers, and the requirement for clinical translation, the review emphasizes the value of interdisciplinary cooperation.</p> Conclusion <p>This review presents a thorough examination of the revolutionary potential of engineered biopolymer-based NFs in wound care, including novel treatment approaches that may greatly improve healing results for patients with issues connected to diabetes.</p> Lay summary <p>DWs, particularly diabetic foot ulcers, present significant challenges in healthcare due to their chronic nature and the complexities associated with healing in diabetic patients. Recent advancements in biopolymer-based NFs have shown promising potential in enhancing the management and healing of these wounds. Engineered NFs are developed through techniques like electrospinning, which allows the production of fibers with diameters in the nanometer range. The engineered biopolymers-based NFs represent a significant advancement in the management of both acute and chronic wounds. Their unique properties, ability, and mechanisms that support wound healing (WH), ultimately making them a promising solution for addressing the challenges posed by DWs.</p> Graphical Abstract <p>Management of diabetic wounds by graft biopolymer containing fabricated nanofibers</p> <p></p>