Scholarlink

Abstract <p>Fibroblast growth factor II (FGF2), or basic fibroblast growth factor (bFGF), is an important regulator in bone and craniofacial development. FGF2 regulates cell survival, proliferation, migration, multilineage differentiation, and stemness in stromal cells. While there is broad interest in utilizing FGF2 for bone and craniofacial tissue repair and regeneration, the literature and reported data are often inconsistent or even controversial due to its multifunctional nature. Therefore, the outcomes are dependent on dose, duration, timing of administration, spatiotemporal pattern of the FGF2 delivery, and the microenvironment. This review paper aims to discuss FGF2 signaling and its related pathways, as well as mechanisms <i>in vitro</i>, <i>in vivo</i>, and in clinical applications of FGF2 in inducing osteogenic differentiation of human mesenchymal stromal cells (hMSCs) for craniofacial bone regeneration.</p> Lay Summary <p>Fibroblast growth factor II (FGF2) regulates bone and craniofacial development, including cell survival, proliferation, migration, multilineage differentiation, and stemness in stromal cells. While there is broad interest in utilizing FGF2 for bone and craniofacial tissue repair and regeneration, the literature and reported data are often inconsistent or even controversial due to the multifunctional nature of FGF2. The outcomes depend on dose, duration, timing of administration, spatiotemporal pattern of the FGF2 delivery, and the microenvironment. This review paper aims to discuss FGF2 signaling pathways, their crosstalk, drug delivery vehicles, and scaffolds for craniofacial bone.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Role of FGF2 in Promoting Osteogenic Differentiation for Craniofacial Bone Regeneration

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月25日

查看全文
  • Xianrui Yang,
  • Peter X. Ma

摘要

Abstract

Fibroblast growth factor II (FGF2), or basic fibroblast growth factor (bFGF), is an important regulator in bone and craniofacial development. FGF2 regulates cell survival, proliferation, migration, multilineage differentiation, and stemness in stromal cells. While there is broad interest in utilizing FGF2 for bone and craniofacial tissue repair and regeneration, the literature and reported data are often inconsistent or even controversial due to its multifunctional nature. Therefore, the outcomes are dependent on dose, duration, timing of administration, spatiotemporal pattern of the FGF2 delivery, and the microenvironment. This review paper aims to discuss FGF2 signaling and its related pathways, as well as mechanisms in vitro, in vivo, and in clinical applications of FGF2 in inducing osteogenic differentiation of human mesenchymal stromal cells (hMSCs) for craniofacial bone regeneration.

Lay Summary

Fibroblast growth factor II (FGF2) regulates bone and craniofacial development, including cell survival, proliferation, migration, multilineage differentiation, and stemness in stromal cells. While there is broad interest in utilizing FGF2 for bone and craniofacial tissue repair and regeneration, the literature and reported data are often inconsistent or even controversial due to the multifunctional nature of FGF2. The outcomes depend on dose, duration, timing of administration, spatiotemporal pattern of the FGF2 delivery, and the microenvironment. This review paper aims to discuss FGF2 signaling pathways, their crosstalk, drug delivery vehicles, and scaffolds for craniofacial bone.