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Purpose <p>This work is a summary of comprehensive analysis of recent advancements, challenges, and future prospects in integrating <i>Aloe vera</i>-based materials for tissue engineering applications.</p> Methods <p>To investigate the role of <i>Aloe vera</i> in tissue engineering, we conducted a literature search using a combination of keywords across Scopus, PubMed, and Web of Science for publications from 2014 to 2024. The most relevant and highly cited articles were selected for inclusion in this study.</p> Results <p>This review highlights recent advancements in <i>Aloe vera</i>-based biomaterials for tissue engineering, particularly hydrogels, scaffolds, and biocomposites. Furthermore, it aims to inspire researchers to explore the untapped potential of <i>Aloe vera</i> in tissue engineering for development of innovative biomedical applications.</p> Conclusion <p>In recent years, its popularity has increased as a natural remedy for various ailments and as a valuable dietary supplement in food industry. With the advancement of tissue engineering, significant progress has been made in developing innovative approaches for tissue repair and regeneration. Tissue scaffolds, which play a crucial role in tissue engineering, are typically designed using natural and synthetic polymer materials. In tissue engineering, <i>Aloe vera</i> has been increasingly incorporated into 3D scaffolds, hydrogels, and composite materials, contributing to wound healing, tissue regeneration, replacement, and drug delivery. When blended with polymers, <i>Aloe vera</i> enhances tensile strength, biocompatibility, and physicochemical properties while reducing toxicity.</p> Lay Summary <p>Researchers are integrating <i>Aloe vera</i> into biomaterials for applications such as skin regeneration, bone repair, and scaffolds for tissue growth. This review explores how <i>Aloe vera</i> can be used in tissue engineering and regenerative medicine. Known for its healing properties, <i>Aloe vera</i> has bioactive compounds that promote cell growth, reduce inflammation, and support wound healing. This review highlights recent advancements, challenges, and future possibilities in using <i>Aloe vera</i> for medical applications.</p>

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Tissue Engineering Applications of Aloe vera L. Burm. F.: A Comprehensive Review

  • 期刊论文

  • 发表日期：

    2025年5月27日

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  • Indira M,
  • Sudarsini B,
  • Naga Lakshmi A,
  • Venkateswarulu T.C

摘要

Purpose

This work is a summary of comprehensive analysis of recent advancements, challenges, and future prospects in integrating Aloe vera-based materials for tissue engineering applications.

Methods

To investigate the role of Aloe vera in tissue engineering, we conducted a literature search using a combination of keywords across Scopus, PubMed, and Web of Science for publications from 2014 to 2024. The most relevant and highly cited articles were selected for inclusion in this study.

Results

This review highlights recent advancements in Aloe vera-based biomaterials for tissue engineering, particularly hydrogels, scaffolds, and biocomposites. Furthermore, it aims to inspire researchers to explore the untapped potential of Aloe vera in tissue engineering for development of innovative biomedical applications.

Conclusion

In recent years, its popularity has increased as a natural remedy for various ailments and as a valuable dietary supplement in food industry. With the advancement of tissue engineering, significant progress has been made in developing innovative approaches for tissue repair and regeneration. Tissue scaffolds, which play a crucial role in tissue engineering, are typically designed using natural and synthetic polymer materials. In tissue engineering, Aloe vera has been increasingly incorporated into 3D scaffolds, hydrogels, and composite materials, contributing to wound healing, tissue regeneration, replacement, and drug delivery. When blended with polymers, Aloe vera enhances tensile strength, biocompatibility, and physicochemical properties while reducing toxicity.

Lay Summary

Researchers are integrating Aloe vera into biomaterials for applications such as skin regeneration, bone repair, and scaffolds for tissue growth. This review explores how Aloe vera can be used in tissue engineering and regenerative medicine. Known for its healing properties, Aloe vera has bioactive compounds that promote cell growth, reduce inflammation, and support wound healing. This review highlights recent advancements, challenges, and future possibilities in using Aloe vera for medical applications.