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<p>Skin wounds arise from various internal and external factors, complicating infection management, chronic wound treatment, and the need for both cosmetic and functional rehabilitation. Diabetic wounds, in particular, pose significant challenges due to impaired healing mechanisms, necessitating innovative therapeutic approaches beyond conventional treatments. Nanoscaffolds have transformed diabetic wound care by enabling precise drug delivery, enhancing tissue regeneration, and improving wound dressings for better moisture retention and infection control. Nanoscaffolds facilitate localized and sustained drug release, accelerating wound closure while minimizing systemic side effects. Additionally, they mimic the extracellular matrix, providing structural support for cellular proliferation and tissue regeneration. Current biomaterials such as collagen, chitosan, gelatin, silk fibroin, alginate, cellulose, and starch have been widely employed in tissue engineering, forming scaffolds, hydrogels, and micro-nanospheres. Nanocomposites, characterized by elastomeric, biomimetic, and antibacterial properties, have emerged as promising injectable materials for wound healing applications. This review explores the pathophysiology of diabetic wounds, their underlying causes, and nanotechnology-driven interventions, with a particular emphasis on nanoscaffold-based dressings. By harnessing nanotechnology, diabetic wound management can be significantly improved through targeted therapies that enhance healing, reduce complications, and optimize patient outcomes. Diabetic wounds are difficult to heal and prone to infection, presenting a major challenge for both patients and healthcare providers. Traditional treatments often lack effectiveness, highlighting the need for new approaches. Nanotechnology offers promising solutions by improving drug delivery, tissue regeneration, and wound dressings. Nanoparticles enable precise medication delivery directly to wounds, enhancing healing and minimizing side effects. Furthermore, nanofibers and scaffolds replicate natural tissue structures, supporting cell growth and repair. Materials like collagen, chitosan, and silk fibroin are used to develop advanced wound healing products. This review emphasizes the transformative potential of nanotechnology in diabetic wound care, offering improved patient outcomes.</p>

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Functionalized Nanoscaffolds for Drug Delivery Using Biomaterials: A Glimmer of Hope in Diabetic Wound Management

  • 期刊论文

  • 发表日期：

    2025年5月6日

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  • Melvin Vincent Dsouza,
  • Suneel Dodamani,
  • Bhaskar Kurangi,
  • Vijay Kumbar,
  • Mehmuda Hussain

摘要

Skin wounds arise from various internal and external factors, complicating infection management, chronic wound treatment, and the need for both cosmetic and functional rehabilitation. Diabetic wounds, in particular, pose significant challenges due to impaired healing mechanisms, necessitating innovative therapeutic approaches beyond conventional treatments. Nanoscaffolds have transformed diabetic wound care by enabling precise drug delivery, enhancing tissue regeneration, and improving wound dressings for better moisture retention and infection control. Nanoscaffolds facilitate localized and sustained drug release, accelerating wound closure while minimizing systemic side effects. Additionally, they mimic the extracellular matrix, providing structural support for cellular proliferation and tissue regeneration. Current biomaterials such as collagen, chitosan, gelatin, silk fibroin, alginate, cellulose, and starch have been widely employed in tissue engineering, forming scaffolds, hydrogels, and micro-nanospheres. Nanocomposites, characterized by elastomeric, biomimetic, and antibacterial properties, have emerged as promising injectable materials for wound healing applications. This review explores the pathophysiology of diabetic wounds, their underlying causes, and nanotechnology-driven interventions, with a particular emphasis on nanoscaffold-based dressings. By harnessing nanotechnology, diabetic wound management can be significantly improved through targeted therapies that enhance healing, reduce complications, and optimize patient outcomes. Diabetic wounds are difficult to heal and prone to infection, presenting a major challenge for both patients and healthcare providers. Traditional treatments often lack effectiveness, highlighting the need for new approaches. Nanotechnology offers promising solutions by improving drug delivery, tissue regeneration, and wound dressings. Nanoparticles enable precise medication delivery directly to wounds, enhancing healing and minimizing side effects. Furthermore, nanofibers and scaffolds replicate natural tissue structures, supporting cell growth and repair. Materials like collagen, chitosan, and silk fibroin are used to develop advanced wound healing products. This review emphasizes the transformative potential of nanotechnology in diabetic wound care, offering improved patient outcomes.