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Purpose <p>Infection and excessive moisture are significant challenges in wound healing. This study aimed to develop a multifunctional wound dressing material with antibacterial properties, moisture management, and tissue regeneration capabilities. Biopolymer polyvinyl alcohol (PVA), gelatin (GN), and physiologically clotted fibrin (PCF) were combined with carbon nanoparticles (CNp) to achieve this.</p> Methods <p>CNp were synthesized via a green method and incorporated into PVA-GN-PCF nanofibers. Characterization was performed using FTIR, TGA, HRSEM, and EDX analysis. Antimicrobial activity was tested against Gram-positive and Gram-negative bacteria. Biocompatibility was evaluated using the human keratinocyte cell line (HaCaT), while biodegradation and gene expression studies analyzed degradation rate and tissue regeneration potential (RUNX2 and BMP-2 markers).</p> Results <p>The PVA-GN-PCF-CNp nanofibers had a size range of 57–182&#xa0;nm and demonstrated superior antibacterial activity compared to controls. Biocompatibility studies confirmed no toxicity to HaCaT cells, and biodegradation testing showed a complete breakdown within 96&#xa0;h. Gene expression analysis revealed upregulation of RUNX2 and BMP-2, suggesting improved tissue regeneration potential.</p> Conclusion <p>The PVA-GN-PCF-CNp nanofiber composite shows strong antibacterial properties, biodegradability, biocompatibility, and tissue regeneration potential, making it a promising material for wound healing applications.</p> Lay Summary <p>Developed a new wound dressing material using biodegradable components and carbon nanoparticles. This material fights bacteria, supports skin cell growth, and breaks down naturally in 96&#xa0;h, making it safe and eco-friendly. It holds great promise for improving wound healing.</p>

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Carbon Nanoparticle-Infused PVA-GN-PCF Nanofibers for Antibacterial, Biodegradable Wound Dressings

  • 期刊论文

  • 发表日期：

    2025年3月31日

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  • Senthil Rethinam

摘要

Purpose

Infection and excessive moisture are significant challenges in wound healing. This study aimed to develop a multifunctional wound dressing material with antibacterial properties, moisture management, and tissue regeneration capabilities. Biopolymer polyvinyl alcohol (PVA), gelatin (GN), and physiologically clotted fibrin (PCF) were combined with carbon nanoparticles (CNp) to achieve this.

Methods

CNp were synthesized via a green method and incorporated into PVA-GN-PCF nanofibers. Characterization was performed using FTIR, TGA, HRSEM, and EDX analysis. Antimicrobial activity was tested against Gram-positive and Gram-negative bacteria. Biocompatibility was evaluated using the human keratinocyte cell line (HaCaT), while biodegradation and gene expression studies analyzed degradation rate and tissue regeneration potential (RUNX2 and BMP-2 markers).

Results

The PVA-GN-PCF-CNp nanofibers had a size range of 57–182 nm and demonstrated superior antibacterial activity compared to controls. Biocompatibility studies confirmed no toxicity to HaCaT cells, and biodegradation testing showed a complete breakdown within 96 h. Gene expression analysis revealed upregulation of RUNX2 and BMP-2, suggesting improved tissue regeneration potential.

Conclusion

The PVA-GN-PCF-CNp nanofiber composite shows strong antibacterial properties, biodegradability, biocompatibility, and tissue regeneration potential, making it a promising material for wound healing applications.

Lay Summary

Developed a new wound dressing material using biodegradable components and carbon nanoparticles. This material fights bacteria, supports skin cell growth, and breaks down naturally in 96 h, making it safe and eco-friendly. It holds great promise for improving wound healing.