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Abstract <p>Fractures treated with immobilization or surgery one of the most common materials used for fracture treatment is titanium (Ti) due to its mechanical properties and biocompatibility. However, the intention to improve Ti alloys has encouraged the exploration of bioceramic coatings like hydroxyapatite (HA), bioglass (BG), and silica (Si). Despite the high costs of HA and BG coatings, Si-coated implants offer an effective alternative. In this context, this systematic review aimed to examine the impact of Si-coated Ti implants on bone healing through in vivo animal studies. The search was conducted according to the orientations of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and the SYRCLE Tool for Quality Assessment. The descriptors of the Medical Subject Headings (MeSH) were defined: (coat*) AND ((bone tissue) OR (hard tissue)) AND ((in vivo) OR (animal)) AND ((silica) OR (silicon dioxide)) AND ((Ti) OR (titanium)). A total of 10 articles were included in the review. Results assessed via histological analysis and macroscopic evaluation showed successful osseointegration and new bone deposition. Also, the implants have not exhibited any sites of inflammation. In conclusion, this review confirms the considerable advantages of incorporating Si to enhance the biological properties of Ti implants for bone regeneration.</p> Lay Summary <p>Titanium (Ti) is a common material for fracture treatment due to its strength and biocompatibility. To improve its properties, bioceramic coatings like hydroxyapatite (HA), bioglass (BG), and silica (Si) have been studied. This review focused on silica-coated Ti implants, a cost-effective alternative to HA and BG, and their effects on bone healing in animal studies. Analyzing 10 studies, researchers found that silica coatings enhanced osseointegration, stimulated new bone growth, and caused no inflammation. These results confirm silica’s potential to improve Ti implants, offering an effective solution for fracture treatment and bone regeneration.</p>

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In Vivo Assessment of Silica-coated Titanium Implants for Improved Osseointegration: a Systematic Review

  • 期刊论文

  • 发表日期：

    2025年3月25日

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  • Giovanna do Espirito Santo,
  • Amanda Sardeli Alqualo,
  • Gustavo Oliva Amaral,
  • Amanda de Souza,
  • Homero Garcia-Motta,
  • Julieta Leticia Merlo,
  • Beatriz Louise Mendes Viegas,
  • João Paulo dos Santos Prado,
  • Karolyne dos Santos Jorge Sousa,
  • Rafael Anaya da Silva Zaratin,
  • Renata Neves Granito,
  • Daniel Araki Ribeiro,
  • Silvia Marcela Ceré,
  • Ana Claudia Rennó

摘要

Abstract

Fractures treated with immobilization or surgery one of the most common materials used for fracture treatment is titanium (Ti) due to its mechanical properties and biocompatibility. However, the intention to improve Ti alloys has encouraged the exploration of bioceramic coatings like hydroxyapatite (HA), bioglass (BG), and silica (Si). Despite the high costs of HA and BG coatings, Si-coated implants offer an effective alternative. In this context, this systematic review aimed to examine the impact of Si-coated Ti implants on bone healing through in vivo animal studies. The search was conducted according to the orientations of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and the SYRCLE Tool for Quality Assessment. The descriptors of the Medical Subject Headings (MeSH) were defined: (coat*) AND ((bone tissue) OR (hard tissue)) AND ((in vivo) OR (animal)) AND ((silica) OR (silicon dioxide)) AND ((Ti) OR (titanium)). A total of 10 articles were included in the review. Results assessed via histological analysis and macroscopic evaluation showed successful osseointegration and new bone deposition. Also, the implants have not exhibited any sites of inflammation. In conclusion, this review confirms the considerable advantages of incorporating Si to enhance the biological properties of Ti implants for bone regeneration.

Lay Summary

Titanium (Ti) is a common material for fracture treatment due to its strength and biocompatibility. To improve its properties, bioceramic coatings like hydroxyapatite (HA), bioglass (BG), and silica (Si) have been studied. This review focused on silica-coated Ti implants, a cost-effective alternative to HA and BG, and their effects on bone healing in animal studies. Analyzing 10 studies, researchers found that silica coatings enhanced osseointegration, stimulated new bone growth, and caused no inflammation. These results confirm silica’s potential to improve Ti implants, offering an effective solution for fracture treatment and bone regeneration.