<p>Potato early dying (PED) is a disease affecting potato crops that generates significant economic losses for the sector. Accurate diagnosis and knowledge of the distribution of the disease, as well as of its epidemiological parameters at the regional level, can be considered as the basis for implementing management strategies. For this reason, the study had the following objectives: (i) identify the causal agent of PED, and (ii) determine the epidemiological parameters of the disease at mesoscale in a producing region of the high tropics in Colombia. Monitoring was carried out on commercial crops in seven provinces of Cundinamarca and affected plants were collected for the isolation of the pathogen. The prevalence of the disease by province was determined over the second half of 2020. Values for climate variables were extracted from Chelsa and soil values from SoilGrids at each plot. Additionally, a survey was carried out on potato producers about crop management with an emphasis on parameters associated with PED, and the relationship between these was evaluated using multivariate methods. The results indicate that the cause of PED is <i>Verticillium</i> spp. The disease was found in all the provinces evaluated, with a variable incidence level between plots. Edaphoclimatic factors such as sand content, average temperature and precipitation and management practices, such as the planting of continuous potato cycles and the use of uncleaned machinery, were related to the prevalence and incidence of the disease at the regional level. The diagnosis made and the regional epidemiological parameters of PED found in this study are the first contribution to the understanding of the disease in potato producing areas in the high tropics.</p>