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Purpose <p>Hair loss, characterized by decreased hair density or thinning, can result from factors such as air pollution and bacterial infections. This study investigated the effects of <i>Bacopa monnieri</i> extract (BME) on hair growth, utilizing a needle-free supersonic atomizer for transdermal delivery. In this study, we investigate an alternative approach to the traditional smear method for evaluating the effects of BCM extract (BME) on hair growth.</p> Methods <p>Various conditions of the transdermal delivered BMEs using a needle-free supersonic atomizer were examined. Hair growth was evaluated through histological analysis, IHC staining, Western blot and Immunofluorescence staining for hair growth related proteins.</p> Results <p>Two major components, Bacopaside I (305.7&#xa0;µg/mL) and Bacopaside IV (94.3&#xa0;µg/mL), were successfully purified and identified in a 1&#xa0;mg/mL BME solution. Histological observations demonstrated that hair growth area was markedly increased in mice treated with BME, BME/HA, and the commercial product minoxidil (MNX) through a needle-free supersonic atomizer. Immunohistochemical staining revealed that follicle area and the expression of hair growth-related markers, CD34 and Wnt10b, were significantly increased after treatment with BME/HA compared with the other BME and MNX groups, suggesting that BME/HA exhibited superior hair growth. Western blot analysis also revealed increased levels of Wnt10b and Wnt3a after treatment with BME, BME/HA, and MNX.</p> Conclusion <p>In this study, the needle-free supersonic atomizer delivering BME, particularly when combined with hyaluronan, into the dermal layer promoted more hair growth compared with the traditional smear method and the commercial MNX.</p>

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Enhanced Hair Growth Through Transdermal Delivery of Bacopa Monnieri Extract Using a Needle-Free Supersonic Atomizer

  • 期刊论文

  • 发表日期：

    2025年8月20日

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  • Yu-Chiuan Wu,
  • Yi-Ping Lin,
  • Ching-Yi Chang,
  • Hsia-Ying Cheng,
  • Tien-Huei Chu,
  • Chien-Chih Chen,
  • Shyh-Ming Kuo

摘要

Purpose

Hair loss, characterized by decreased hair density or thinning, can result from factors such as air pollution and bacterial infections. This study investigated the effects of Bacopa monnieri extract (BME) on hair growth, utilizing a needle-free supersonic atomizer for transdermal delivery. In this study, we investigate an alternative approach to the traditional smear method for evaluating the effects of BCM extract (BME) on hair growth.

Methods

Various conditions of the transdermal delivered BMEs using a needle-free supersonic atomizer were examined. Hair growth was evaluated through histological analysis, IHC staining, Western blot and Immunofluorescence staining for hair growth related proteins.

Results

Two major components, Bacopaside I (305.7 µg/mL) and Bacopaside IV (94.3 µg/mL), were successfully purified and identified in a 1 mg/mL BME solution. Histological observations demonstrated that hair growth area was markedly increased in mice treated with BME, BME/HA, and the commercial product minoxidil (MNX) through a needle-free supersonic atomizer. Immunohistochemical staining revealed that follicle area and the expression of hair growth-related markers, CD34 and Wnt10b, were significantly increased after treatment with BME/HA compared with the other BME and MNX groups, suggesting that BME/HA exhibited superior hair growth. Western blot analysis also revealed increased levels of Wnt10b and Wnt3a after treatment with BME, BME/HA, and MNX.

Conclusion

In this study, the needle-free supersonic atomizer delivering BME, particularly when combined with hyaluronan, into the dermal layer promoted more hair growth compared with the traditional smear method and the commercial MNX.