Scholarlink

<p>Chirality is a ubiquitous structural feature that profoundly affects the efficacy of tumor therapy by regulating key physiological processes. However, the link between chirality and the therapeutic properties of metal nanomaterials, particularly atomically precise metal nanoclusters (NCs), remains poorly understood. Herein, atomically precise Au<sub>25</sub> NCs protected by chiral cysteine (cys) ligands (L-Au<sub>25</sub>(cys)<sub>18</sub>, D-Au<sub>25</sub>(cys)<sub>18</sub>, and Rac-Au<sub>25</sub>(cys)<sub>18</sub>) were constructed and systematically investigated to elucidate the association between chirality and their tumor therapeutic performance. Although no significant difference in enzyme-like activity was observed among the three NCs, Rac-Au<sub>25</sub>(cys)<sub>18</sub> exhibited enhanced reactive oxygen species generation capacity under 808 nm laser irradiation, achieving superior phototherapeutic effects in both <i>in vitro</i> and <i>in vivo</i> tumor models. The chiral Au<sub>25</sub> NCs induced distinct cell death pathways: L-Au<sub>25</sub>(cys)<sub>18</sub> primarily triggered ferroptosis, D-Au<sub>25</sub>(cys)<sub>18</sub> induced both ferroptosis and apoptosis, and all three NCs activated disulfidptosis. This work clarifies the correlation between chiral structures and the tumor therapeutic performance of gold NCs, providing experimental insights and theoretical support for the design of novel chiral nanomaterials and the optimization of precise tumor phototherapeutic strategies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Phototherapeutic efficacy and cell death pathways of atomically precise chiral Au25 nanoclusters in tumor therapy

  • 期刊论文

  • 发表日期：

    2026年7月28日

查看全文
  • Ai Liu,
  • Jiazhu Zheng,
  • Ziyan Zhao,
  • Yiming Wang,
  • Yan Sun,
  • Afang Dai,
  • Zunfu Hu,
  • Yunqiang Sun,
  • Zibao Gan,
  • Xiuwen Zheng

摘要

Chirality is a ubiquitous structural feature that profoundly affects the efficacy of tumor therapy by regulating key physiological processes. However, the link between chirality and the therapeutic properties of metal nanomaterials, particularly atomically precise metal nanoclusters (NCs), remains poorly understood. Herein, atomically precise Au25 NCs protected by chiral cysteine (cys) ligands (L-Au25(cys)18, D-Au25(cys)18, and Rac-Au25(cys)18) were constructed and systematically investigated to elucidate the association between chirality and their tumor therapeutic performance. Although no significant difference in enzyme-like activity was observed among the three NCs, Rac-Au25(cys)18 exhibited enhanced reactive oxygen species generation capacity under 808 nm laser irradiation, achieving superior phototherapeutic effects in both in vitro and in vivo tumor models. The chiral Au25 NCs induced distinct cell death pathways: L-Au25(cys)18 primarily triggered ferroptosis, D-Au25(cys)18 induced both ferroptosis and apoptosis, and all three NCs activated disulfidptosis. This work clarifies the correlation between chiral structures and the tumor therapeutic performance of gold NCs, providing experimental insights and theoretical support for the design of novel chiral nanomaterials and the optimization of precise tumor phototherapeutic strategies.