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<p>Minimally invasive yet effective treatment of nasopharyngeal carcinoma (NPC) is a major challenge, particularly because of the anatomical complexity of the nasopharynx and the limitations of conventional therapies in achieving precise targeting and sufficient therapeutic efficacy. Here, we present a multifunctional platform derived from heat-triggered electrospray self-healing porous poly(lactic-<i>co</i>-glycolic acid) (PLGA) microspheres encapsulated with indocyanine green (ICG), sequentially coated with tannic acid-Fe<sup>3+</sup> (TAF) metal-phenolic network and fibronectin (FN) for targeted photothermal/chemodynamic combined therapy of NPC. The prepared functional microspheres (PI-TAF@FN) with an average size of 1.9 µm demonstrate excellent colloidal stability, heat-induced self-healing performance, and high photothermal conversion efficiency (51.4%). These microspheres can target NPC cells through FN-mediated integrin recognition and can exert ICG/TAF-mediated photothermal therapy under an 808-nm laser irradiation and TAF-mediated chemodynamic therapy for enhanced cancer cell apoptosis induction <i>in vitro</i>. The functional PI-TAF@FN microsphere-mediated combined photothermo-chemodynamic therapy enables effective treatment of a mouse NPC model with minimal systemic toxicity. Furthermore, the PI-TAF@FN microspheres with dual components of TAF and ICG enable multi-mode FN-targeted <i>T</i><sub>1</sub>-weighted magnetic resonance/fluorescence/thermal imaging of tumors for precision NPC treatment. The developed electrospray self-healing porous microspheres may be developed as a unique theranostic platform that can integrate different therapeutic and diagnostic components for precision theranostics of different types of tumors.</p>

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Electrospray self-healing porous polymer microspheres for multimode imaging and combined photothermal/chemodynamic therapy of nasopharyngeal carcinoma

  • 期刊论文

  • 发表日期：

    2026年5月26日

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  • Yifan Huang,
  • Aiyu Li,
  • Meijuan He,
  • Huxiao Sun,
  • Zhuo Li,
  • Jiahui Liu,
  • Jiansong Xing,
  • Han Wang,
  • Mingwu Shen,
  • Xiangyang Shi

摘要

Minimally invasive yet effective treatment of nasopharyngeal carcinoma (NPC) is a major challenge, particularly because of the anatomical complexity of the nasopharynx and the limitations of conventional therapies in achieving precise targeting and sufficient therapeutic efficacy. Here, we present a multifunctional platform derived from heat-triggered electrospray self-healing porous poly(lactic-co-glycolic acid) (PLGA) microspheres encapsulated with indocyanine green (ICG), sequentially coated with tannic acid-Fe3+ (TAF) metal-phenolic network and fibronectin (FN) for targeted photothermal/chemodynamic combined therapy of NPC. The prepared functional microspheres (PI-TAF@FN) with an average size of 1.9 µm demonstrate excellent colloidal stability, heat-induced self-healing performance, and high photothermal conversion efficiency (51.4%). These microspheres can target NPC cells through FN-mediated integrin recognition and can exert ICG/TAF-mediated photothermal therapy under an 808-nm laser irradiation and TAF-mediated chemodynamic therapy for enhanced cancer cell apoptosis induction in vitro. The functional PI-TAF@FN microsphere-mediated combined photothermo-chemodynamic therapy enables effective treatment of a mouse NPC model with minimal systemic toxicity. Furthermore, the PI-TAF@FN microspheres with dual components of TAF and ICG enable multi-mode FN-targeted T1-weighted magnetic resonance/fluorescence/thermal imaging of tumors for precision NPC treatment. The developed electrospray self-healing porous microspheres may be developed as a unique theranostic platform that can integrate different therapeutic and diagnostic components for precision theranostics of different types of tumors.