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<p>The development of bioadhesives that can rapidly and reliably seal wet tissues remains a formidable challenge due to the trade-off between mechanical compliance and swelling-induced instability in physiological environments. To address this limitation, we report a hydrophobic effect-medicated bioadhesive, consisting of methacrylated phenylalanine hyaluronic acid (HA) adhesive (MPAH), which integrates ultrafast photo-crosslinking with strong tissue adhesion, and low swelling feature. Through the synergistic incorporation of hydrophobic phenylalanine groups and <i>N</i>-hydroxysuccinimide (NHS) esters, MPAH forms gelation within 2 s under UV irradiation, significantly outperforming commercial fibrin glues. The adhesive shows a lap shear strength of ∼35 kPa on wet porcine casings, an extensibility exceeding 60%, and a compressive strength of ∼475 kPa. In contrast to conventional HA hydrogels and commercial fibrin glues, MPAH maintains a low equilibrium swelling ratio below 30% in PBS over 16 days. This behavior might be attributed to the hydrophobic interactions and π-π stacking within the network, effectively preventing tissue compression and interfacial detachment. In rat wound models of linear incision and full-thickness skin defects, MPAH demonstrated rapid sealing, reduced inflammation, and accelerated re-epithelialization compared to fibrin glue and sutures, highlighting its potential as an effective bioadhesive for wound closure and soft tissue repair.</p>

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Engineering an ultrafast gelling and low swelling hyaluronic acid bioadhesive for stable wet-tissue adhesion and enhanced wound healing

  • 期刊论文

  • 发表日期：

    2026年5月6日

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  • Pan Sun,
  • Jiadong Wu,
  • Xianjia Lin,
  • Yang Tian,
  • Jing Sun

摘要

The development of bioadhesives that can rapidly and reliably seal wet tissues remains a formidable challenge due to the trade-off between mechanical compliance and swelling-induced instability in physiological environments. To address this limitation, we report a hydrophobic effect-medicated bioadhesive, consisting of methacrylated phenylalanine hyaluronic acid (HA) adhesive (MPAH), which integrates ultrafast photo-crosslinking with strong tissue adhesion, and low swelling feature. Through the synergistic incorporation of hydrophobic phenylalanine groups and N-hydroxysuccinimide (NHS) esters, MPAH forms gelation within 2 s under UV irradiation, significantly outperforming commercial fibrin glues. The adhesive shows a lap shear strength of ∼35 kPa on wet porcine casings, an extensibility exceeding 60%, and a compressive strength of ∼475 kPa. In contrast to conventional HA hydrogels and commercial fibrin glues, MPAH maintains a low equilibrium swelling ratio below 30% in PBS over 16 days. This behavior might be attributed to the hydrophobic interactions and π-π stacking within the network, effectively preventing tissue compression and interfacial detachment. In rat wound models of linear incision and full-thickness skin defects, MPAH demonstrated rapid sealing, reduced inflammation, and accelerated re-epithelialization compared to fibrin glue and sutures, highlighting its potential as an effective bioadhesive for wound closure and soft tissue repair.