<p>Circularly polarized (CP) photodetectors hold significant promise for applications in optical communication, polarization imaging, and target recognition, etc. Chiral organic materials offer unique advantages for the development of CP photodetectors owing to their structural tunability, solution processability, and excellent compatibility with flexible substrates. However, the difficulties in synthesis and enantiomeric separation, as well as intrinsically weak chiroptical responses of chiral organic materials, have hindered further improvements in device performance and practical applications. In recent years, advances in the design and synthesis of chiral organic molecules, combined with solid-state assembly strategies, have led to remarkable enhancements in the performance of organic CP photodetectors. In this review, we summarize recent developments in chiral organic materials for CP photodetection from molecular design and supramolecular engineering perspectives. Potential applications of organic CP photodetectors are also discussed. This review aims to deepen the understanding of this emerging research area, foster its future development, and attract broad research interest from different disciplines.</p>