Scholarlink

<p>Chiral nanomaterials have sparked significant interest in antibacterial strategies. Here, a novel spatiotemporally precise synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) is pioneered for antibacterial applications. Circularly polarized light (CPL)-activated chiral molybdenum-doped carbon dots (L-Mo-CDs, D-Mo-CDs) are developed using chiral tartaric acid as a precursor. Notably, D-Mo-CDs selectively respond to left-handed CPL (LCP), along with a selective response of L-Mo-CDs to right-handed CPL (RCP). Moreover, D-Mo-CDs exhibit enhanced reactive oxygen species (ROS) generation and higher photothermal conversion efficiency (PCE) compared to L-Mo-CDs. <i>In vitro</i> antibacterial experiments demonstrate that D-Mo-CDs exhibit excellent antibacterial efficacy. Furthermore, <i>in vivo</i> animal studies reveal their remarkable wound healing efficacy achieved via reducing inflammation, accelerating the formation of blood vessels and promoting collagen deposition. This study takes a novel sight to chiral nanomaterials in antibacterial applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Circularly polarized light activated chiral molybdenum-doped carbon dots for spatiotemporally synergistic antibacterial strategy

  • 期刊论文

  • 发表日期：

    2026年2月13日

查看全文
  • Tianliang Li,
  • Lixing Lin,
  • Zeyu Li,
  • Xuetao Yan,
  • Lifei Chen,
  • Yingying Chen,
  • Zhenzhen Li,
  • Lingyan Feng

摘要

Chiral nanomaterials have sparked significant interest in antibacterial strategies. Here, a novel spatiotemporally precise synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) is pioneered for antibacterial applications. Circularly polarized light (CPL)-activated chiral molybdenum-doped carbon dots (L-Mo-CDs, D-Mo-CDs) are developed using chiral tartaric acid as a precursor. Notably, D-Mo-CDs selectively respond to left-handed CPL (LCP), along with a selective response of L-Mo-CDs to right-handed CPL (RCP). Moreover, D-Mo-CDs exhibit enhanced reactive oxygen species (ROS) generation and higher photothermal conversion efficiency (PCE) compared to L-Mo-CDs. In vitro antibacterial experiments demonstrate that D-Mo-CDs exhibit excellent antibacterial efficacy. Furthermore, in vivo animal studies reveal their remarkable wound healing efficacy achieved via reducing inflammation, accelerating the formation of blood vessels and promoting collagen deposition. This study takes a novel sight to chiral nanomaterials in antibacterial applications.