<p>Respiratory sensors, capable of monitoring human respiratory status, are essential for health management, disease prevention, and early diagnosis. Achieving real-time monitoring of respiratory status requires sensors with fast and sensitive respiratory response, as well as high stability. Herein, we demonstrate an amino-modified graphdiyne (NH₂-GDY)-based sensor for real-time monitoring of human respiratory status. Compared to pristine graphdiyne, the amino-functionalized NH₂-GDY exhibits enhanced adsorption capacity for water molecules. Furthermore, its enlarged nanoporous structure facilitates the migration of water molecules, enabling rapid adsorption/desorption of water molecules. This respiratory sensor demonstrates ultra-fast and ultra-sensitive respiratory responses, coupled with remarkable flexibility and stability. When integrated into a wearable electronic system, it achieves real-time monitoring of sleep apnea syndrome. This work highlights the feasibility of novel carbon-based respiratory sensors in advanced health monitoring applications.</p>