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<p>Magnesium alloys have gained significant attention as bone implant materials because of their outstanding biodegradability and biocompatibility. Nevertheless, their rapid degradation and bacterial infection subsequent to implantation restrict their application. Herein, zeolite imidazolate framework-8@3,4,9,10-perylenetetracarboxylic diimide (ZIF-8@PD) coatings were <i>in situ</i> fabricated on the micro-arc oxidation (MAO) coated AZ31 alloys by two-step and one-step (defined as OS) methods based on planar ligand of PD. Results displayed that the corrosion current density (<i>i</i><sub>corr</sub>) of MAO/ZIF-8@PD and MAO/ZIF-8@PD (OS) coatings decreased by three and two orders of magnitude, respectively, compared to that of the MAO coating, exhibiting good corrosion protection due to the physical barrier effect of its 2D-co-3D metal-organic frameworks (MOFs) structure. Under the irradiation of 808 nm near infrared laser, the photothermal and photodynamic activity conferred by planar molecular PD coupled with the contact killing effect of released Zn<sup>2+</sup> ions resulted in bactericidal rates of ⩾99.5% against <i>E. coli</i> and <i>S. aureus</i> for both coatings. Additionally, the photothermal conversion efficiencies of the MAO/ZIF-8@PD and MAO/ZIF-8@PD (OS) coatings are 44.01% and 48.57%, respectively. Interestingly, the different sources of Zn<sup>2+</sup> ions led to two different 2D-co-3D MOFs structures with different degradation and antibacterial behavior, which will facilitate the application of magnesium alloys in biomedical fields.</p>

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In vitro degradation and photo-stimulated antibacterial activity of 2D-co-3D MOFs coating on AZ31 magnesium alloy

  • 期刊论文

  • 发表日期：

    2026年1月4日

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  • Hao Chen,
  • Xiao-Tong Yu,
  • Cheng-Xu Yi,
  • Lan-Yue Cui,
  • Yu Wang,
  • Shuo-Qi Li,
  • Cheng-Bao Liu,
  • Fen Zhang,
  • Wei-Xiang Sun,
  • Rong-Chang Zeng

摘要

Magnesium alloys have gained significant attention as bone implant materials because of their outstanding biodegradability and biocompatibility. Nevertheless, their rapid degradation and bacterial infection subsequent to implantation restrict their application. Herein, zeolite imidazolate framework-8@3,4,9,10-perylenetetracarboxylic diimide (ZIF-8@PD) coatings were in situ fabricated on the micro-arc oxidation (MAO) coated AZ31 alloys by two-step and one-step (defined as OS) methods based on planar ligand of PD. Results displayed that the corrosion current density (icorr) of MAO/ZIF-8@PD and MAO/ZIF-8@PD (OS) coatings decreased by three and two orders of magnitude, respectively, compared to that of the MAO coating, exhibiting good corrosion protection due to the physical barrier effect of its 2D-co-3D metal-organic frameworks (MOFs) structure. Under the irradiation of 808 nm near infrared laser, the photothermal and photodynamic activity conferred by planar molecular PD coupled with the contact killing effect of released Zn2+ ions resulted in bactericidal rates of ⩾99.5% against E. coli and S. aureus for both coatings. Additionally, the photothermal conversion efficiencies of the MAO/ZIF-8@PD and MAO/ZIF-8@PD (OS) coatings are 44.01% and 48.57%, respectively. Interestingly, the different sources of Zn2+ ions led to two different 2D-co-3D MOFs structures with different degradation and antibacterial behavior, which will facilitate the application of magnesium alloys in biomedical fields.