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<p>In comparison with the 660 nm light-triggered type II photosensitizers (PSs) for high oxygen consumption, type I photo-sensitizers that could be triggered by 808 nm near-infrared (NIR) light to achieve effective electron transfer show great application potential in anoxic microenvironments for photodynamic therapy (PDT) due to their lower oxygen dependence. However, developing type I PSs still remains a challenge due to the low energy of NIR light and preferred utilization of type II rather than type I process of PSs under the matched energy levels. Herein, co-assembly of 5,10,15,20-tetrakis-(4-aminophenyl)-porphyrin (TAPP) with <i>N</i>-carbobenzyloxy-L-leucine (Cbz-Leu) affords a supramolecular nano-PS (TAPP@Cbz-Leu). TAPP@Cbz-Leu significantly produces superoxide anions (O<sub>2</sub><sup>•−</sup>) when triggered by NIR light (808 nm). The noncovalent tight binding between TAPP and Cbz-Leu was revealed to induce an increase in the photoinduced electron transfer from Cbz-Leu to the triplet TAPP, generating TAPP<sup>•−</sup> and promoting the formation of O<sub>2</sub><sup>•−</sup> Furthermore, TAPP@Cbz-Leu possess excellent photothermal property under NIR light (808 nm) irradiation. <i>In vivo</i> studies disclose the good antibacterial effect of TAPP@Cbz-Leu on <i>MRSA</i>-infected animal wound models and can effectively promote wound healing. The present result seems to represent the first example of converting type II PS into the type I PS by means of a simple co-assembly strategy.</p>

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Porphyrin-assembled nano-photosensitizer with near-infrared response for highly efficient type I photodynamic and photothermal therapy

  • 期刊论文

  • 发表日期：

    2025年5月14日

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  • Wei Su,
  • Lei Cen,
  • Dong Yang,
  • Chenxiang Lin,
  • Jun-An Xiao,
  • Peiyuan Li,
  • Kang Wang,
  • Jianzhuang Jiang

摘要

In comparison with the 660 nm light-triggered type II photosensitizers (PSs) for high oxygen consumption, type I photo-sensitizers that could be triggered by 808 nm near-infrared (NIR) light to achieve effective electron transfer show great application potential in anoxic microenvironments for photodynamic therapy (PDT) due to their lower oxygen dependence. However, developing type I PSs still remains a challenge due to the low energy of NIR light and preferred utilization of type II rather than type I process of PSs under the matched energy levels. Herein, co-assembly of 5,10,15,20-tetrakis-(4-aminophenyl)-porphyrin (TAPP) with N-carbobenzyloxy-L-leucine (Cbz-Leu) affords a supramolecular nano-PS (TAPP@Cbz-Leu). TAPP@Cbz-Leu significantly produces superoxide anions (O2•−) when triggered by NIR light (808 nm). The noncovalent tight binding between TAPP and Cbz-Leu was revealed to induce an increase in the photoinduced electron transfer from Cbz-Leu to the triplet TAPP, generating TAPP•− and promoting the formation of O2•− Furthermore, TAPP@Cbz-Leu possess excellent photothermal property under NIR light (808 nm) irradiation. In vivo studies disclose the good antibacterial effect of TAPP@Cbz-Leu on MRSA-infected animal wound models and can effectively promote wound healing. The present result seems to represent the first example of converting type II PS into the type I PS by means of a simple co-assembly strategy.