In this paper, we present two new geometric constants related to isosceles orthogonality \(M(X,\alpha ,\beta )\) and \(M_2(X,\alpha ,\beta )\) , which are generalizations of the rectangular constant proposed by Joly. First, we give upper and lower bounds of these geometric constants. Then we characterize Hilbert spaces in terms of these constants. Furthermore, the relationship between these geometric constants and uniformly non-squareness is also discussed. Finally, we give a characterization of Radon planes with an affine regular hexagonal unit sphere by means of the constants \(M(X,\alpha ,\beta )\) and \(M_2(X,\alpha ,\beta )\) .