<p>Titanium dioxide is one of the most common compounds, due to its thermal chemical stability and special electrostatic, mechanical, and optical properties, which is used in the manufacturing of various chemicals, such as pigments, rubber, plastic, and paper. The current research aims to develop an efficient technique to enrich titanium dioxide from iron slag by optimizing the operational parameters, using the central composite method. The grade of titanium dioxide in the prepared sample was 2 wt%, and after the pretreatment of grinding and gravity separation, a product with a grade of 3.15 wt% titanium dioxide and 12.78 wt% of total iron was obtained. This product was roasted by sodium carbonate, sodium sulfate, and sodium hydroxide. The best condition for alkaline purification of the sample was obtained by sodium carbonate at 500&#xa0;°C, Na₂CO₃/Slag ratio: 1.4 for 120 min. By employing the central composite design (CCD), four parameters of temperature, time, liquid/solid ratio, and sulfuric acid concentration were investigated. After obtaining the mathematical model of the reaction, the optimal conditions were obtained as the temperature of 85&#xa0;°C, time of 235 min, liquid/solid ratio of 15 g/g, and acid concentration of 2.4 mol/L, and the experimental recovery under these conditions was 81.32%. The kinetic study of the process showed that the Diffusion control model controls the reaction speed using the penetration process, and the activation energy was calculated as 5.85 kJ/mol.</p> Graphical Abstract <p></p>