<p>Hybrid micro and nanocomposites reinforced with 1.5 weight% Al₂O₃ and 0.5 weight% MoS₂ in ZA-27 alloy were manufactured using a stir casting process assisted by an ultrasonification approach. SEM and EDS analysis used to investigate microstructure and chemical composition of ZA27 hybrid nanocomposites. Dry sliding tribological behaviour of hybrid nanocomposites under different operating conditions examined using wear and friction testing equipment. Response Surface Methodology (RSM) approach is employed for experimental planning with a software design of experiments for characteristics of ZA-27 hybrid nanocomposites. The results show wear resistance of hybrid nanocomposite increases with distance and speed, while friction coefficient decreases with load and speed. Load and sliding speed are two most important parameters determining hybrid nanocomposites friction coefficient and wear behaviour. The wear rate of hybrid nanocomposites is influenced by interactions of load-distance and speed-load factors. The predictive model of wear rate and friction coefficient of ZA-27/Al₂O₃/MoS₂ hybrid micro and nanocomposites were developed by using RSM. Confirmation tests showed a discrepancy between projected and experimental values for wear rate and coefficient of friction of 1.8% and 4.2%, respectively. A scanning electron microscope is utilized to analyze microstructure of hybrid micro and nanocomposite worm’s surface.</p> Graphical Abstract <p></p>