Purpose of Review <p>This review aims to critically analyze research on the association between sleep and migraine, examine shared pathophysiology, and propose treatment approaches.</p> Recent Findings <p>Sleep disorders, such as insomnia and restless legs syndrome, have significant comorbidity with migraine and are associated with higher migraine burden. Across the migraine attack, sleep symptoms are commonly reported during the prodrome and fatigue dominates the postdrome. Neurobiological studies support shared neuroanatomical structures and neurotransmitters, including the hypothalamus, pituitary adenylate cyclase-activating polypeptide (PACAP), dopamine, serotonin, calcitonin gene-related peptide (CGRP), and orexin. Clinical trials suggest that treating insomnia, particularly with cognitive behavioral therapy, can reduce migraine frequency and severity, offering a dual benefit for patients.</p> Summary <p>Understanding the shared mechanisms and clinical overlap between sleep disturbances and migraine can inform integrated, multimodal treatment strategies. Further research is needed to investigate causal relationships and optimize patient-centered care.</p>

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Sleep and Migraine: Neurobiological Insights and Therapeutic Approaches

  • Alana Fretes Burgos,
  • Mark Burish,
  • Seung-Hee Yoo,
  • Angeliki Vgontzas

摘要

Purpose of Review

This review aims to critically analyze research on the association between sleep and migraine, examine shared pathophysiology, and propose treatment approaches.

Recent Findings

Sleep disorders, such as insomnia and restless legs syndrome, have significant comorbidity with migraine and are associated with higher migraine burden. Across the migraine attack, sleep symptoms are commonly reported during the prodrome and fatigue dominates the postdrome. Neurobiological studies support shared neuroanatomical structures and neurotransmitters, including the hypothalamus, pituitary adenylate cyclase-activating polypeptide (PACAP), dopamine, serotonin, calcitonin gene-related peptide (CGRP), and orexin. Clinical trials suggest that treating insomnia, particularly with cognitive behavioral therapy, can reduce migraine frequency and severity, offering a dual benefit for patients.

Summary

Understanding the shared mechanisms and clinical overlap between sleep disturbances and migraine can inform integrated, multimodal treatment strategies. Further research is needed to investigate causal relationships and optimize patient-centered care.