Purpose of Review <p>Daytime napping, a brief sleep episode during the day, appears to have mixed health effects. This review systematically explores the relationship between daytime napping frequency and health outcomes by synthesizing results from published Mendelian randomization (MR) studies, a method which help mitigate confounding and reverse causality commonly observed in traditional epidemiological research.</p> Recent Findings <p>A total of 35 studies spanning seven major disease categories were identified, with cardiovascular, neurological, and metabolic outcomes being the most frequently investigated in MR. Of the 89 investigated outcomes, 36% of studies suggested increased disease risk, 54% reported no associations, and 10% suggested decreased disease risk with more frequent daytime napping. Generally, not all MR findings aligned with existing epidemiological research.</p> Summary <p>The current evidence from MR does not provide a definitive conclusion regarding the health effects of daytime napping. Future research should consider additional dimensions of napping beyond frequency and integrate both genetic and non-genetic approaches in diverse populations.</p>

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Daytime Napping in Adults: Benefits or Risks? Insights from Mendelian Randomization Studies

  • Aarohi Gupta,
  • Hassan S. Dashti

摘要

Purpose of Review

Daytime napping, a brief sleep episode during the day, appears to have mixed health effects. This review systematically explores the relationship between daytime napping frequency and health outcomes by synthesizing results from published Mendelian randomization (MR) studies, a method which help mitigate confounding and reverse causality commonly observed in traditional epidemiological research.

Recent Findings

A total of 35 studies spanning seven major disease categories were identified, with cardiovascular, neurological, and metabolic outcomes being the most frequently investigated in MR. Of the 89 investigated outcomes, 36% of studies suggested increased disease risk, 54% reported no associations, and 10% suggested decreased disease risk with more frequent daytime napping. Generally, not all MR findings aligned with existing epidemiological research.

Summary

The current evidence from MR does not provide a definitive conclusion regarding the health effects of daytime napping. Future research should consider additional dimensions of napping beyond frequency and integrate both genetic and non-genetic approaches in diverse populations.