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Purpose of review <p>To summarize current approaches to the evaluation and treatment of fatigue in patients with systemic, autoimmune rheumatic diseases (SARD).</p> Recent findings <p>The mechanisms of fatigue in SARD include both disease-related (peripheral) and individual general health (central) factors and both need to be measured and understood. Fibromyalgia is the most important co-morbidity to account for persistent fatigue in the SARD.</p> Summary <p>Pain and fatigue are closely aligned.The discordance between fatigue measures and disease activity is explained by central, rather than peripheral mechanisms. When targeted pharmacologic treatment achieves disease remission, residual significant fatigue and pain need to be treated with individualized, biopsychosocial management.</p>

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Evaluation and Management of Fatigue in Patients with Systemic, Autoimmune Rheumatic Disease

  • 期刊论文

  • 发表日期：

    2025年10月14日

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  • Don L. Goldenberg

摘要

Purpose of review

To summarize current approaches to the evaluation and treatment of fatigue in patients with systemic, autoimmune rheumatic diseases (SARD).

Recent findings

The mechanisms of fatigue in SARD include both disease-related (peripheral) and individual general health (central) factors and both need to be measured and understood. Fibromyalgia is the most important co-morbidity to account for persistent fatigue in the SARD.

Summary

Pain and fatigue are closely aligned.The discordance between fatigue measures and disease activity is explained by central, rather than peripheral mechanisms. When targeted pharmacologic treatment achieves disease remission, residual significant fatigue and pain need to be treated with individualized, biopsychosocial management.