Background <p>Revisiting fundamental concepts during the post-clerkship phase of medical school promotes integration into clinical medicine. Our course uses evolutionarily derived hematologic adaptations to deepen students’ understanding of pathophysiology.</p> Methods <p>This week-long curriculum incorporated interactive seminars, laboratory experiments, and off-site activities. Students’ perceptions of course value, knowledge, and impact were evaluated using pre-course, immediate post-course, and follow-up Likert surveys. Paired <i>t</i>-tests were used to compare pre- and post-course scores.</p> Results and Discussion <p>Our course increased students’ confidence and sustained interest in hematology. These attitudes persisted into residency. This approach models the use of comparative and experiential methods to enhance hematology education.</p>