<p>The influence of negative life events (NLE) on adolescents' depressed mood is well established. However, the underlying psychological mechanisms remain unclear. This study examined the psychological mechanisms linking NLE to depressed mood, with a focus on childhood trauma (CT) and recent negative life events (RNLE). A total of 1,164 high-school students participated in the survey, and network analysis was used to examine relationships among CT, RNLE, and depressed mood. Additionally, mediation analyses examined the roles of experience of pleasure (EP) and maladaptive cognitive emotion regulation (MCER), and the moderating effect of resilience was also tested. Network analysis indicated that emotional abuse and interpersonal stress occupied central positions in the network. Furthermore, EP and MCER significantly mediated the associations between negative life events and depressed mood, and resilience moderated the links among NLE, EP, MCER, and depressed mood. By integrating network analysis with moderated mediation modeling, the study clarifies the pathways through which different types of NLE affect depressed mood in adolescents and highlights the potential of interventions that enhance cognitive emotion regulation and resilience. Specifically, enhancing adolescents' cognitive emotion regulation and resilience may help mitigate the impact of negative life events on depression.</p>